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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 331-360 amino acids from the central region of human ADAMTS5|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Matrix cross-linking-mediated mechanotransduction promotes posttraumatic osteoarthritis.
PA5-14350 was used in western blot to assess the role of matrix-mediated mechanotransduction in osteoarthritis pathogenesis
|Kim JH,Lee G,Won Y,Lee M,Kwak JS,Chun CH,Chun JS||Proceedings of the National Academy of Sciences of the United States of America (112:9424)||2015|
A disintegrin and metalloproteinase with thrombospondin motifs 5; ADAM-TS 5; ADAMTS-5; ADAMTS11, ADMP2; ADMP-2; Aggrecanase-2; Implantin
9530092O11Rik; ADAM-TS5; ADAMTS1; ADAMTS11; Adamts5; AI481094; ASMP-2