|Tested species reactivity||Human, Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Human disintegrin and metalloproteinase with thrombospondin motifs 5|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
PA5-27165 targets ADAMTS5 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-27165 immunogen is human disintegrin and metalloproteinase with thrombospondin motifs 5.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Galnt1 is required for normal heart valve development and cardiac function.
PA5-27165 was used in immunohistochemistry - paraffin section to study heart valve development and cardiac function in Galnt1 KO mice
|Tian E,Stevens SR,Guan Y,Springer DA,Anderson SA,Starost MF,Patel V,Ten Hagen KG,Tabak LA||PloS one (10:null)||2015|