Immunogen sequence: LGEGKATTAH DLSGKLGTPK KEINRVLYSL AKKGKLQKEA GTPPLWKIAV STQAWNQHSG VVRPDGHSQG APNSDPSLEP EDRNSTSVSE DLLEPFIAVS A; Positive Samples: U-87MG, A549, DU145, HeLa, HepG2; Cellular Location: Cytoplasm, Nucleus, Nucleus, nucleolus
MYO18A may link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking.
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Protein Aliases: 136 kDa double-stranded RNA-binding protein; ADA; Adenosine Deaminase; adenosine deaminase acting on RNA 1-A; adenosine deaminase, RNA-specific; Double-stranded RNA-specific adenosine deaminase; DRADA; dsRNA adenosine deaminase; dsRNA adeonosine deaminase; IFI-4; interferon-induced protein 4; Interferon-inducible protein 4; K88DSRBP; p136; RNA adenosine deaminase 1; RNA-specific adenosine deaminase p110 form; RNA-specific adenosine deaminase p150 form
Gene Aliases: ADAR; ADAR1; Adar1p110; Adar1p150; AGS6; AV242451; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88DSRBP; mZaADAR; P136