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This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
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Protein Aliases: AC5; adcy5; Adenylate cyclase type 5; Adenylate cyclase type V; Adenylyl cyclase 5; adenylyl cyclase type V; ATP pyrophosphate-lyase 5
Gene Aliases: AC5; ADCY5; AW121902; FDFM
UniProt ID: (Human) O95622, (Rat) Q04400, (Mouse) P84309
Entrez Gene ID: (Human) 111, (Rat) 64532, (Mouse) 224129
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