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Proteintech
ADCY6 Polyclonal Antibody
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Product Details
14616-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ADCY6 Fusion Protein Ag6218 (310-655 aa encoded by BC064923)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AEVSQRQAF QETRGYIQAR LHLQHENRQQ ERLLLSVLPQ HVAMEMKEDI NTKKEDMMFH KIYIQKHDNV SILFADIEGF TSLASQCTAQ ELVMTLNELF ARFDKLAAEN HCLRIKILGD CYYCVSGLPE ARADHAHCCV EMGVDMIEAI SLVREVTGVN VNMRVGIHSG RVHCGVLGLR KWQFDVWSND VTLANHMEAG GRAGRIHITR ATLQYLNGDY EVEPGRGGER NAYLKEQHIE TFLILGASQK RKEEKAMLAK LQRTRANSME GLMPRWVPDR AFSRTKDSKA FRQMGIDDSS KDNRGTQDAL NPEDEVDEFL SRAIDARSID QLRKDHVRRF LLTFQRE (310-655 aa encoded by BC064923 )
Target Information
This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AC6; ACVI; Adenylate cyclase type 6; Adenylate cyclase type VI; Adenylyl cyclase 6; ATP pyrophosphate-lyase 6; Ca(2+)-inhibitable adenylyl cyclase; DKFZp779F075; KIAA0422; unnamed protein product
Gene Aliases: AC6; ACVI; ADCY6; ADCYB; KIAA0422; LCCS8; mKIAA0422
UniProt ID: (Human) O43306, (Rat) Q03343
Entrez Gene ID: (Human) 112, (Rat) 25289, (Mouse) 11512
nucleotide binding
adenylate cyclase activity
protein kinase C binding
protein binding
ATP binding
lyase activity
phosphorus-oxygen lyase activity
protein kinase binding
metal ion binding
SNARE binding
receptor binding
calcium- and calmodulin-responsive adenylate cyclase activity
scaffold protein binding
cAMP biosynthetic process
dopamine receptor signaling pathway
negative regulation of neuron projection development
intracellular signal transduction
cellular response to prostaglandin E stimulus
cellular response to catecholamine stimulus
maintenance of protein location in plasma membrane
cyclic nucleotide biosynthetic process
renal water homeostasis
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-activating serotonin receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
negative regulation of urine volume
regulation of blood vessel diameter
cellular response to vasopressin
cellular response to forskolin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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