Peptide sequence: NSEKFVKAKA LGATDCLNPR DLHKPIQEVI IELTKGGVDF ALDCAGGSET
Sequence homology: Cow: 86%; Dog: 86%; Human: 100%; Pig: 86%; Rabbit: 79%; Rat: 79%
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.
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Protein Aliases: ADH-2; ADH2; Alcohol dehydrogenase 4; Alcohol dehydrogenase 4 (class II); alcohol dehydrogenase class II; Alcohol dehydrogenase class II pi chain; alcohol dehydrogenase II; aldehyde reductase; class II alcohol dehydrogenase, pi subunit; epididymis secretory protein Li 4; pi polypeptide
Gene Aliases: Ac1002; ADH-1; ADH-2; ADH4; BOS_6460; HEL-S-4
UniProt ID: (Human) P08319