Immunogen sequence: MGTKGKVIKC KAAIAWEAGK PLCIEEVEVA PPKAHEVRIQ IIATSLCHTD ATVIDSKFEG LAFPVIVGHE AAGIVESIGP GVTNVKPGDK VIPLYAPLCR KCKFCLSPLT NLCGKISNLK SPASDQQLME DKTSRFTCKG KPVYHFFGTS TFSQYTVVSD INLAKIDDDA NLERVCLLGC GFSTGYGAAI NNAKVTPGST CAVFGLGGVG LSAVMGCKAA GASRIIGIDI NSEKFVKAKA LGATDCLNPR DLHKPIQEVI IELTKGGVDF ALDCAGGSET MKAALDCTTA GWGSCTFIGV AAGSKGLTIF PEELIIGRTI NGTFFGGWKS VDSIPKLVTD YKNKKFNLDA LVTHTLPFDK ISEAFDLMNQ GKSVRTILIF; Positive Samples: Mouse liver; Cellular Location: Cytoplasm
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.
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Protein Aliases: ADH2; Alcohol dehydrogenase 4; Alcohol dehydrogenase class II; Alcohol dehydrogenase class II pi chain; Alcohol dehydrogenase II; aldehyde reductase; All-trans-retinol dehydrogenase [NAD(+)] ADH4; class II alcohol dehydrogenase, pi subunit; class II type ADH; epididymis secretory protein Li 4
Gene Aliases: Ac1002; ADH-1; ADH-2; Adh2; ADH4; HEL-S-4