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Invitrogen
ADH7 Polyclonal Antibody
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FIGURE: 1 / 2
ADH7 Antibody (PA5-104370) in IHC (P)
Immunohistochemistry analysis of ADH7 in human gastric cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ADH7 polyclonal antibody (Product # PA5-104370) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-104370
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ADH7(Accession P40394), corresponding to amino acid residues D235-E285.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ADH7.
Target Information
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alcohol dehydrogenase class 4 mu/sigma chain; Alcohol dehydrogenase class IV mu/sigma chain; alcohol dehydrogenase VII; alcohol dehydrogenase-7; All-trans-retinol dehydrogenase [NAD(+)] ADH7; class IV alcohol dehydrogenase, mu or sigma subunit; class IV sigma-1 alcohol dehydrogenase; class IV sigmasigma alcohol dehydrogenase; Gastric alcohol dehydrogenase; Omega-hydroxydecanoate dehydrogenase ADH7; ret; Retinol dehydrogenase; unnamed protein product
Gene Aliases: ADH4; ADH7
UniProt ID: (Human) P40394, (Rat) P41682
Entrez Gene ID: (Human) 131, (Rat) 171178
alcohol dehydrogenase (NAD) activity
aldehyde oxidase activity
retinol dehydrogenase activity
zinc ion binding
oxidoreductase activity
retinol binding
ethanol binding
metal ion binding
receptor antagonist activity
omega-hydroxydecanoate dehydrogenase activity
alcohol dehydrogenase activity, zinc-dependent
protein homodimerization activity
NAD binding
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
retinoid metabolic process
lipid metabolic process
response to bacterium
fatty acid omega-oxidation
monocarboxylic acid metabolic process
retinol metabolic process
retinoic acid metabolic process
response to ethanol
ethanol metabolic process
ethanol catabolic process
ethanol oxidation
oxidation-reduction process
extracellular negative regulation of signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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