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Invitrogen

ADORA1 Polyclonal Antibody

View all (13) ADORA1 antibodies

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Product Details

PA5-33319

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

27-40 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Hamster, Human, Mouse, Non-human primate, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human Adenosine A1 Receptor.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2550703

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Hamster, Elephant, Pig (100%) Dog, Pan ….

Target Information

Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The A1AR is a glycoprotein that can activate Gi and Go proteins in vitro. In intact cells, agonist occupation of the A1AR has been shown to cause pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, a stimulation of phospholipase C resulting in mobilization of intracellular calcium stores. Activation of potassium channels by A1AR has been intensively studied in relation to its dramatic effects on the cardiovascular system. A1AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release. In white adipocytes A1AR inhibits lipolysis and stimulates glucose uptake. Other tissues also express A1AR including kidney and testis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A1 adenosine receptor; adenosine A1 receptor; Adenosine receptor A1; adenosine receptor A1-like protein; adenylate cyclase inhibitor; ADO-A1 receptor; ADORA1; AR; GPCR; lacks the N-terminus and first three transmembrane domains; lacks the N-terminus and the first three transmembrane domains; unnamed protein product

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Gene Aliases: A1-AR; A1AR; A1R; AA1R; ADORA1; AI848715; BB176431; RDC7; Ri

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UniProt ID: (Bovine) P28190, (Human) P30542, (Mouse) Q60612, (Rat) P25099

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Entrez Gene ID: (Bovine) 282133, (Pig) 606743, (Human) 134, (Mouse) 11539, (Rat) 29290, (Chinese hamster) 100751346

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Function(s)
G-protein coupled adenosine receptor activity G-protein coupled receptor binding purine nucleoside binding G-protein coupled receptor activity protein binding heat shock protein binding G-protein beta/gamma-subunit complex binding heterotrimeric G-protein binding macromolecular complex binding protein heterodimerization activity phospholipase C activity signal transducer activity G-protein coupled receptor
Process(es)
adenosine receptor signaling pathway negative regulation of leukocyte migration regulation of glomerular filtration negative regulation of inflammatory response regulation of sensory perception of pain excitatory postsynaptic potential negative regulation of mucus secretion negative regulation of long term synaptic depression temperature homeostasis response to hypoxia regulation of respiratory gaseous exchange by neurological system process negative regulation of acute inflammatory response positive regulation of peptide secretion positive regulation of systemic arterial blood pressure negative regulation of systemic arterial blood pressure protein targeting to membrane phagocytosis inflammatory response signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway cell-cell signaling nervous system development negative regulation of cell proliferation negative regulation of glutamate secretion response to purine-containing compound lipid catabolic process negative regulation of synaptic transmission, GABAergic positive regulation of nucleoside transport negative regulation of neurotrophin production positive regulation of dephosphorylation G-protein coupled purinergic nucleotide receptor signaling pathway vasodilation negative regulation of circadian sleep/wake cycle, sleep negative regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of apoptotic process positive regulation of potassium ion transport positive regulation of MAPK cascade negative regulation of blood pressure positive regulation of blood pressure negative regulation of hormone secretion cognition leukocyte migration detection of temperature stimulus involved in sensory perception of pain negative regulation of lipid catabolic process positive regulation of lipid catabolic process negative regulation of synaptic transmission, glutamatergic fatty acid homeostasis regulation of cardiac muscle contraction long term synaptic depression mucus secretion triglyceride homeostasis regulation of cardiac muscle cell contraction apoptotic signaling pathway regulation of presynaptic cytosolic calcium ion concentration negative regulation of long-term synaptic potentiation activation of MAPKK activity positive regulation of protein dephosphorylation negative regulation of renal sodium excretion positive regulation of epidermal growth factor-activated receptor activity negative regulation of heart contraction negative regulation of vasodilation regulation of synaptic plasticity negative regulation of cardiac muscle contraction relaxation of vascular smooth muscle regulation of vasodilation
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