Proteintech

ADORA2A Polyclonal Antibody

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ADORA2A Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 51092-1-AP ( ADORA2A Antibody) at dilution of 1:100 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

ADORA2A Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 51092-1-AP ( ADORA2A Antibody) at dilution of 1:100 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

ADORA2A Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 51092-1-AP (ADORA2A antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

ADORA2A Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 51092-1-AP (ADORA2A antibody) at dilution of 1:200 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

ADORA2A Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 51092-1-AP (ADORA2A antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

ADORA2A Antibody in Western Blot (WB) — Rat brain tissue were subjected to SDS PAGE followed by western blot with 51092-1-AP (ADORA2A antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

ADORA2A Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with 51092-1-AP (ADORA2A antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Product Details

51092-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:200-1:1,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	ADORA2A Fusion Protein Ag0470 (300-412 aa encoded by BC013780) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.24 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: RKIIRSHVL RQQEPFKAAG TSARVLAAHG SDGEQVSLRL NGHPPGVWAN GSAPHPERRP NGYALGLVSG GSAQESQGNT GLPDVELLSH ELKGVCPEPP GLDDPLAQDG AGVS (300-412 aa encoded by B C013780)

Target Information

ADORA2A is a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. This protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A2a receptor; Adenosine A2a-receptor; Adenosine receptor A2a; adenosine receptor subtype A2a; hA2aR

Gene Aliases: A2AAR; A2aR; AA2AR; ADENO; ADORA2; ADORA2A; Adora2l1; RDC8

UniProt ID: (Human) P29274, (Mouse) Q60613, (Rat) P30543

Entrez Gene ID: (Human) 135, (Mouse) 11540, (Rat) 25369

Molecular Function: G-protein coupled receptor

adenosine receptor signaling pathway cAMP biosynthetic process phagocytosis apoptotic process inflammatory response cellular defense response adenylate cyclase-modulating G-protein coupled receptor signaling pathway cell-cell signaling central nervous system development blood coagulation sensory perception blood circulation positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway cellular protein metabolic process synaptic transmission, dopaminergic response to amphetamine regulation of transcription, DNA-templated negative regulation of protein kinase activity signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway protein kinase C-activating G-protein coupled receptor signaling pathway synaptic transmission, cholinergic locomotory behavior negative regulation of cell proliferation positive regulation of glutamate secretion positive regulation of acetylcholine secretion, neurotransmission regulation of norepinephrine secretion positive regulation of cAMP biosynthetic process response to caffeine positive regulation of synaptic transmission, GABAergic synaptic transmission, glutamatergic positive regulation of urine volume positive regulation of renal sodium excretion negative regulation of locomotion vasodilation eating behavior negative regulation of vascular permeability negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to alkaloid negative regulation of neuron apoptotic process positive regulation of circadian sleep/wake cycle, sleep negative regulation of alpha-beta T cell activation astrocyte activation regulation of synaptic plasticity neuron projection morphogenesis positive regulation of protein secretion negative regulation of inflammatory response regulation of mitochondrial membrane potential membrane depolarization regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential inhibitory postsynaptic potential prepulse inhibition positive regulation of apoptotic signaling pathway response to drug

Process(es)

G-protein coupled adenosine receptor activity protein binding enzyme binding identical protein binding signal transducer activity G-protein coupled receptor activity type 5 metabotropic glutamate receptor binding protein heterodimerization activity alpha-actinin binding