Invitrogen

ADORA2A Polyclonal Antibody

1 Published Figure
9 References
View all (19) ADORA2A antibodies

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ADORA2A Polyclonal Antibody

Product Details

PA1-042

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 4 publications 4 publications

Immunohistochemistry (IHC)

-
View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:10-1:100
-

Immunoprecipitation (IP)

Assay-dependent
-

Proximity Ligation Assay (PLA) (PLA)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Published species

Dog, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues E(373) S H G D M G L P D V E L L S H E L K(391) of canine A2aAR.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.69 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2257858

Product Specific Information

PA1-042 detects adenosine receptor A2a (A2aAR) in human, rat, mouse and canine tissues. This antibody does not detect other AR subtypes.

PA1-042 has been successfully used in Western blot, ICC/IF, immunohistochemistry and immunoprecipitation procedures. By Western blot, this antibody detects an ~45 kDa protein from canine striatum representing A2aAR. Immunohistochemical staining of A2aAR in human hippocampus with PA1-042 yields a pattern consistent with plasma membrane staining.

The PA1-042 immunogen is a synthetic peptide corresponding to residues E(373) S H G D M G L P D V E L L S H E L K(391) of canine A2aAR.

Target Information

ADORA2A is a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. This protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: A2a receptor; Adenosine A2a-receptor; Adenosine receptor A2a; adenosine receptor subtype A2a; AR; hA2aR; unnamed protein product

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Gene Aliases: A2AAR; A2aR; AA2AR; ADENO; ADORA2; ADORA2A; Adora2l1; RDC8

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UniProt ID: (Human) P29274, (Dog) P11617, (Mouse) Q60613, (Rat) P30543

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Entrez Gene ID: (Human) 135, (Dog) 403960, (Mouse) 11540, (Rat) 25369

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Function(s)
G-protein coupled adenosine receptor activity protein binding enzyme binding identical protein binding signal transducer activity G-protein coupled receptor activity type 5 metabotropic glutamate receptor binding protein heterodimerization activity alpha-actinin binding G-protein coupled receptor
Process(es)
adenosine receptor signaling pathway cAMP biosynthetic process phagocytosis apoptotic process inflammatory response cellular defense response adenylate cyclase-modulating G-protein coupled receptor signaling pathway cell-cell signaling central nervous system development blood coagulation sensory perception blood circulation positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway cellular protein metabolic process synaptic transmission, dopaminergic response to amphetamine adenylate cyclase-activating G-protein coupled receptor signaling pathway locomotory behavior positive regulation of synaptic transmission, GABAergic eating behavior negative regulation of alpha-beta T cell activation negative regulation of inflammatory response inhibitory postsynaptic potential positive regulation of apoptotic signaling pathway regulation of transcription, DNA-templated negative regulation of protein kinase activity signal transduction G-protein coupled receptor signaling pathway protein kinase C-activating G-protein coupled receptor signaling pathway synaptic transmission, cholinergic negative regulation of cell proliferation positive regulation of glutamate secretion positive regulation of acetylcholine secretion, neurotransmission regulation of norepinephrine secretion positive regulation of cAMP biosynthetic process response to caffeine synaptic transmission, glutamatergic positive regulation of urine volume positive regulation of renal sodium excretion negative regulation of locomotion vasodilation negative regulation of vascular permeability negative regulation of cysteine-type endopeptidase activity involved in apoptotic process response to alkaloid negative regulation of neuron apoptotic process positive regulation of circadian sleep/wake cycle, sleep astrocyte activation regulation of synaptic plasticity neuron projection morphogenesis positive regulation of protein secretion regulation of mitochondrial membrane potential membrane depolarization regulation of calcium ion transport positive regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential prepulse inhibition response to drug
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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