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ADORA2B encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17.
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Protein Aliases: A2b receptor; Adenosine receptor A2b; HGNC:264; netrin-1 receptor
Gene Aliases: ADORA2; ADORA2B
Molecular Function: G-protein coupled receptor