Peptide sequence: RSCKAPKVVR KADRSRTSIL IICILITGLG IISVISHLTK RRRSQRNRRV
Sequence homology: Cow: 75%; Horse: 93%; Human: 100%; Pig: 85%; Rabbit: 77%
Adenosine is involved in a variety of processes, including the synthesis of urea, the anti-inflammatory response and the inhibition of protein synthesis The adenosine receptors, including adenosine A1-R, adenosine A2A-R, adenosine A2B-R and adenosine A3-R, are integral membrane proteins that are members of the G protein-coupled receptor family. The A1-R protein mediates ureagenesis in a partially calcium-dependent manner. Adenosine is known to mediate coronary vasodilation via the A2A-R receptor. Collagen synthesis and total protein synthesis are inhibited in certain cells by adenosine, acting via the A2B receptors. Activation of the A3-R receptor inhibits the induction of the cytokine TNF alpha and blocks the endotoxin CD14 receptor signal transduction pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AD026; Adenosine A3-R; Adenosine receptor A3; BA552M11.5; RP11-552M11.7
Gene Aliases: A3AR; ADORA3
UniProt ID: (Human) P0DMS8
Entrez Gene ID: (Human) 140
Molecular Function: G-protein coupled receptor