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Proteintech
ADRA1A Polyclonal Antibody
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FIGURE: 1 / 7
ADRA1A Antibody (19777-1-AP) in WB
Mouse brain tissue lysates were subjected to SDS PAGE followed by western blot with (Product # 19777-1-AP) ADRA1A-Specific antibody at dilution of 1:1,000 incubated at room temperature for 1.5 hours without or with blocking peptide (1.4 µg peptide was used to block the binding of 1.0 µg antibody).
Product Details
19777-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to ADRA1A.
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence. A1AR subtypes are found in numerous tissues and have been shown to be involved in the regulation of blood pressure due to changes in vascular tone and cardiac output. Effects on uterine contraction, hepatic glucose metabolism, heat shock protein 70 (HSP70), proto-oncogene expression, and mitogenesis have been linked to A1AR activation. Norepinephrine can increase nitric oxide synthase (NOS) levels in the hypothalamus by activating alpha-1 AR which may indirectly suppress the release of luteinizing hormone (LH), the androgens, estrogen, and progesterone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADA1; adrenergic alpha 1c receptor; adrenergic receptor alpha 1c subtype; adrenergic receptor, alpha 1a; adrenergic receptor, alpha 1c; adrenergic, alpha-1A-, receptor; alpha 1A-adrenoceptor; alpha 1A-adrenoreceptor; alpha 1C-adrenergic receptor; Alpha-1A adrenergic receptor; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; Alpha1C-AR; G protein coupled receptor
Gene Aliases: ADRA1A; ADRA1C; ADRA1L1; ALPHA1AAR
UniProt ID: (Human) P35348, (Mouse) P97718, (Rat) P43140
Entrez Gene ID: (Human) 148, (Mouse) 11549, (Rat) 29412
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
positive regulation of heart rate by epinephrine-norepinephrine
positive regulation of the force of heart contraction by epinephrine-norepinephrine
positive regulation of systemic arterial blood pressure
apoptotic process
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
adult heart development
aging
negative regulation of cell proliferation
response to hormone
cell growth
positive regulation of synaptic transmission, GABAergic
negative regulation of Rho protein signal transduction
organ growth
intracellular signal transduction
response to drug
positive regulation of MAPK cascade
positive regulation of action potential
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
micturition
calcium ion transport into cytosol
positive regulation of cardiac muscle contraction
positive regulation of ERK1 and ERK2 cascade
adenylate cyclase-activating adrenergic receptor signaling pathway
positive regulation of protein kinase C signaling
pilomotor reflex
regulation of muscle contraction
positive regulation of heart rate
regulation of vasoconstriction
regulation of cardiac muscle contraction
adrenergic receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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