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ADRA1A Polyclonal Antibody

View all (15) alpha-1a Adrenergic Receptor antibodies

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ADRA1A Polyclonal Antibody

Product Details

BS-0600R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Alpha-1A adrenergic receptor, amino acids 201-300.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence. A1AR subtypes are found in numerous tissues and have been shown to be involved in the regulation of blood pressure due to changes in vascular tone and cardiac output. Effects on uterine contraction, hepatic glucose metabolism, heat shock protein 70 (HSP70), proto-oncogene expression, and mitogenesis have been linked to A1AR activation. Norepinephrine can increase nitric oxide synthase (NOS) levels in the hypothalamus by activating alpha-1 AR which may indirectly suppress the release of luteinizing hormone (LH), the androgens, estrogen, and progesterone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ADA1; adrenergic alpha 1c receptor; adrenergic receptor alpha 1c subtype; adrenergic receptor, alpha 1a; adrenergic receptor, alpha 1c; adrenergic, alpha-1A-, receptor; alpha 1A-adrenoceptor; alpha 1A-adrenoreceptor; alpha 1C-adrenergic receptor; alpha 1c-adrenoceptor subtype; Alpha-1A adrenergic receptor; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; Alpha1C-AR; G protein coupled receptor; GPCR; unnamed protein product

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Gene Aliases: ADRA1A; ADRA1C; ADRA1L1; ALPHA1AAR

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UniProt ID: (Human) P35348, (Mouse) P97718, (Rat) P43140

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Entrez Gene ID: (Human) 148, (Mouse) 11549, (Rat) 29412

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Function(s)
G-protein coupled receptor activity adrenergic receptor activity alpha1-adrenergic receptor activity protein binding protein heterodimerization activity signal transducer activity G-protein coupled receptor
Process(es)
MAPK cascade negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure positive regulation of heart rate by epinephrine-norepinephrine positive regulation of the force of heart contraction by epinephrine-norepinephrine apoptotic process regulation of muscle contraction smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling adult heart development regulation of blood pressure negative regulation of cell proliferation response to xenobiotic stimulus response to hormone negative regulation of autophagy positive regulation of cardiac muscle hypertrophy regulation of vasoconstriction positive regulation of synaptic transmission, GABAergic organ growth intracellular signal transduction positive regulation of MAPK cascade positive regulation of action potential positive regulation of vasoconstriction positive regulation of smooth muscle contraction regulation of cardiac muscle contraction positive regulation of cardiac muscle contraction cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway pilomotor reflex neuron-glial cell signaling positive regulation of systemic arterial blood pressure activation of phospholipase C activity aging positive regulation of heart rate cell growth negative regulation of Rho protein signal transduction response to drug micturition calcium ion transport into cytosol positive regulation of protein kinase C signaling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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