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Proteintech
ADRA1B Polyclonal Antibody
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Product Details
19776-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to ADRA1B.
Target Information
The alpha-1b adrenoceptor is an Adrenergic Receptor that causes contraction of smooth muscle cells and thereby controls vascular tone, blood pressure, and accelerates the development of atherosclerosis. Decreased alpha-1b adrenoceptor is associated with benign prostatic hyperplasia (BPH). This adrenergic receptor also acts as a proto-oncogene when transfected into cell lines where constitutive activation of the receptor induces neoplastic transformation. The alpha-1b adrenoceptor has been documented in adrenal, aorta, blood, various brain regions, eye, heart, kidney, liver, prostate, spinal cord, and spleen. ESTs have been isolated from kidney (normal and cancer) and lung carcinoma libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADA1B; Adrenergic alpha 1B- receptor; adrenergic receptor, alpha 1b; adrenergic, alpha-1B-, receptor; alpha 1B-adrenoceptor; alpha 1B-adrenoreceptor; Alpha-1B adrenergic receptor; Alpha-1B adrenoceptor; Alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; alpha1B-adrenergic receptor
Gene Aliases: [a]1b; ADRA1; ADRA1B; ALPHA1BAR
UniProt ID: (Human) P35368
Entrez Gene ID: (Human) 147, (Rat) 24173, (Mouse) 11548
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
multicellular organism development
cell proliferation
intracellular signal transduction
glucose homeostasis
positive regulation of MAPK cascade
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
regulation of cardiac muscle contraction
adenylate cyclase-activating adrenergic receptor signaling pathway
blood vessel remodeling
response to amphetamine
vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure
positive regulation of heart rate by epinephrine-norepinephrine
positive regulation of the force of heart contraction by epinephrine-norepinephrine
adult heart development
locomotory behavior
visual learning
response to hormone
cell growth
regulation of vasoconstriction
negative regulation of Rho protein signal transduction
organ growth
response to drug
response to morphine
response to estrogen
negative regulation of glycogen catabolic process
positive regulation of glycogen catabolic process
behavioral response to cocaine
response to steroid hormone
adrenergic receptor signaling pathway
regulation of muscle contraction
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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