Proteintech

ADRB2 Polyclonal Antibody

20 References

View all (38) beta-2 Adrenergic Receptor antibodies

Datasheet

Protocols

Tech Support

Datasheet

Protocols

Tech Support

Antibody Testing Data (5)

ADRB2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

ADRB2 Antibody (13096-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human heart tissue slide using 13096-1-AP ( ADRB2 Antibody) at dilution of 1:50 (under 40x lens).

Product Image Gallery

ADRB2 Antibody in Western Blot (WB) — Mouse heart tissue were subjected to SDS PAGE followed by western blot with 13096-1-AP (ADRB2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

ADRB2 Antibody in Flow Cytometry (Flow) — 1X10^6 PC-3 cells were stained with 0.2ug ADRB2 antibody (13096-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) with dilution 1:1500.

Product Details

13096-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ADRB2 Fusion Protein Ag3715 (220-413 aa encoded by BC012481)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.38 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

This antibody detects ADRB2 with an apparent molecular weight of 50-55 kDa as has been shown by some researches.

Immunogen sequence: SRVFQEAKR QLQKIDKSEG RFHVQNLSQV EQDGRTGHGL RRSSKFCLKE HKALKTLGII MGTFTLCWLP FFIVNIVHVI QDNLIRKEVY ILLNWIGYVN SGFNPLIYCR SPDFRIAFQE LLCLRRSSLK AYGNGYSSNG NTGEQSGYHV EQEKENKLLC EDLPGTEDFV GHQGTVPSDN IDSPGRNCST NDSLL (220-413 aa encoded by BC012481)

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

10-Gingerol Enhances the Effect of Taxol in Triple-Negative Breast Cancer via Targeting ADRB2 Signaling.

Drug design, development and therapy

Liang Y,Wu G,Luo T,Xie H,Zuo Q,Huang P,Li H,Chen L,Lu H,Chen Q

Wed Feb 01 00:00:00 EST 2023

10-Gingerol Enhances the Effect of Taxol in Triple-Negative Breast Cancer via Targeting ADRB2 Signaling.

Drug design, development and therapy

Liang Y,Wu G,Luo T,Xie H,Zuo Q,Huang P,Li H,Chen L,Lu H,Chen Q

Wed Feb 01 00:00:00 EST 2023

10-Gingerol Enhances the Effect of Taxol in Triple-Negative Breast Cancer via Targeting ADRB2 Signaling.

Drug design, development and therapy

Liang Y,Wu G,Luo T,Xie H,Zuo Q,Huang P,Li H,Chen L,Lu H,Chen Q

Wed Feb 01 00:00:00 EST 2023

10-Gingerol Enhances the Effect of Taxol in Triple-Negative Breast Cancer via Targeting ADRB2 Signaling.

Drug design, development and therapy

Liang Y,Wu G,Luo T,Xie H,Zuo Q,Huang P,Li H,Chen L,Lu H,Chen Q

Wed Feb 01 00:00:00 EST 2023

The Secretome of Parental and Bone Metastatic Breast Cancer Elicits Distinct Effects in Human Osteoclast Activity after Activation of β2 Adrenergic Signaling.

Biomolecules

Conceição F,Sousa DM,Tojal S,Lourenço C,Carvalho-Maia C,Estevão-Pereira H,Lobo J,Couto M,Rosenkilde MM,Jerónimo C,Lamghari M

Thu Mar 30 00:00:00 EDT 2023

The Secretome of Parental and Bone Metastatic Breast Cancer Elicits Distinct Effects in Human Osteoclast Activity after Activation of β2 Adrenergic Signaling.

Biomolecules

Conceição F,Sousa DM,Tojal S,Lourenço C,Carvalho-Maia C,Estevão-Pereira H,Lobo J,Couto M,Rosenkilde MM,Jerónimo C,Lamghari M

Thu Mar 30 00:00:00 EDT 2023

β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis.

Open medicine (Warsaw, Poland)

Yang X,Liang X,Guo H,Ma L,Jian L,Zhao X,Wang J,Yang L,Meng Z,Jin Q

Sat Jul 16 00:00:00 EDT 2022

β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis.

Open medicine (Warsaw, Poland)

Yang X,Liang X,Guo H,Ma L,Jian L,Zhao X,Wang J,Yang L,Meng Z,Jin Q

Sat Jul 16 00:00:00 EDT 2022

β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis.

Open medicine (Warsaw, Poland)

Yang X,Liang X,Guo H,Ma L,Jian L,Zhao X,Wang J,Yang L,Meng Z,Jin Q

Sat Jul 16 00:00:00 EDT 2022

Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis.

Journal of translational medicine

Zhou Z,Shu Y,Bao H,Han S,Liu Z,Zhao N,Yuan W,Jian C,Shu X

Tue Jun 07 00:00:00 EDT 2022

Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination.

Diabetes

Niu Y,Jiang H,Yin H,Wang F,Hu R,Hu X,Peng B,Shu Y,Li Z,Chen S,Guo F

Sun May 01 00:00:00 EDT 2022

β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Chen N,Ge MM,Li DY,Wang XM,Liu DQ,Ye DW,Tian YK,Zhou YQ,Chen JP

Wed Dec 01 00:00:00 EST 2021

β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Chen N,Ge MM,Li DY,Wang XM,Liu DQ,Ye DW,Tian YK,Zhou YQ,Chen JP

Wed Dec 01 00:00:00 EST 2021

β-Adrenoceptor Activation in Breast MCF-10A Cells Induces a Pattern of Catecholamine Production Similar to that of Tumorigenic MCF-7 Cells.

International journal of molecular sciences

Amaro F,Silva D,Reguengo H,Oliveira JC,Quintas C,Vale N,Gonçalves J,Fresco P

Tue Oct 27 00:00:00 EDT 2020

β-Adrenoceptor Activation in Breast MCF-10A Cells Induces a Pattern of Catecholamine Production Similar to that of Tumorigenic MCF-7 Cells.

International journal of molecular sciences

Amaro F,Silva D,Reguengo H,Oliveira JC,Quintas C,Vale N,Gonçalves J,Fresco P

Tue Oct 27 00:00:00 EDT 2020

Translatome and Transcriptome Profiling of Hypoxic-Induced Rat Cardiomyocytes.

Molecular therapy. Nucleic acids

Shen Z,Zeng L,Zhang Z

Fri Dec 04 00:00:00 EST 2020

SMN deficiency causes pain hypersensitivity in a mild SMA mouse model through enhancing excitability of nociceptive dorsal root ganglion neurons.

Scientific reports

Qu R,Yao F,Zhang X,Gao Y,Liu T,Hua Y

Wed Apr 24 00:00:00 EDT 2019

Interplay between sympathetic nervous system and inflammation in aseptic loosening of hip joint replacement.

Scientific reports

Ribeiro-da-Silva M,Vasconcelos DM,Alencastre IS,Oliveira MJ,Linhares D,Neves N,Costa G,Henrique R,Lamghari M,Alves CJ

Tue Oct 30 00:00:00 EDT 2018

Interplay between sympathetic nervous system and inflammation in aseptic loosening of hip joint replacement.

Scientific reports

Ribeiro-da-Silva M,Vasconcelos DM,Alencastre IS,Oliveira MJ,Linhares D,Neves N,Costa G,Henrique R,Lamghari M,Alves CJ

Tue Oct 30 00:00:00 EDT 2018

Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation.

Proceedings of the National Academy of Sciences of the United States of America

Gao V,Suzuki A,Magistretti PJ,Lengacher S,Pollonini G,Steinman MQ,Alberini CM

Tue Jul 26 00:00:00 EDT 2016

Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation.

Proceedings of the National Academy of Sciences of the United States of America

Gao V,Suzuki A,Magistretti PJ,Lengacher S,Pollonini G,Steinman MQ,Alberini CM

Tue Jul 26 00:00:00 EDT 2016

Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation.

Proceedings of the National Academy of Sciences of the United States of America

Gao V,Suzuki A,Magistretti PJ,Lengacher S,Pollonini G,Steinman MQ,Alberini CM

Tue Jul 26 00:00:00 EDT 2016

Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation.

Proceedings of the National Academy of Sciences of the United States of America

Gao V,Suzuki A,Magistretti PJ,Lengacher S,Pollonini G,Steinman MQ,Alberini CM

Tue Jul 26 00:00:00 EDT 2016

Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.

Oncology reports

Wei WJ,Shen CT,Song HJ,Qiu ZL,Luo QY

Thu Sep 01 00:00:00 EDT 2016

Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.

Oncology reports

Wei WJ,Shen CT,Song HJ,Qiu ZL,Luo QY

Thu Sep 01 00:00:00 EDT 2016

Propranolol as a novel adjunctive treatment for head and neck squamous cell carcinoma.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale

Wolter NE,Wolter JK,Enepekides DJ,Irwin MS

Mon Oct 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: Adrenergic beta 2- receptor surface; adrenergic receptor, beta 2; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; adrenoceptor beta 2, surface; AR beta2; beta 2-AR; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; beta2-Adrenoreceptor; catecholamine receptor; HGNC:286

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Gene Aliases: Adrb-2; ADRB2; ADRB2R; ADRBR; B2AR; Badm; BAR; BETA2AR; Gpcr7

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UniProt ID: (Human) P07550, (Mouse) P18762

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Entrez Gene ID: (Human) 154, (Mouse) 11555, (Rat) 24176

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Molecular Function: G-protein coupled receptor

Function(s)

Process(es)

G-protein alpha-subunit binding beta2-adrenergic receptor activity protein binding drug binding adenylate cyclase binding potassium channel regulator activity B2 bradykinin receptor binding protein complex binding dopamine binding ionotropic glutamate receptor binding protein homodimerization activity epinephrine binding norepinephrine binding signal transducer activity G-protein coupled receptor activity adrenergic receptor activity enzyme binding PDZ domain binding

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ADRB2 Polyclonal Antibody

ADRB2 Antibody (13096-1-AP) in IHC (P)

Product Details

13096-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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