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Invitrogen
ADSL Polyclonal Antibody
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FIGURE: 1 / 2
ADSL Antibody (PA5-29964) in IHC (P)
ADSL Polyclonal Antibody detects ADSL protein at cytosol on mouse fore brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse fore brain. ADSL Polyclonal Antibody (Product # PA5-29964) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-29964
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human ADSL. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.34 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: A431, H1299, HeLa, HepG2.
Predicted reactivity: Mouse (97%), Rat (95%), Zebrafish (84%), Xenopus laevis (90%), Pig (97%), Chicken (91%), Chimpanzee (98%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein that is involved in both purine biosynthesis and in the formation of adenosine monophosphate (AMP) from inosine monophosphate. Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis, namely the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and the subsequent removal of fumarate from adenylosuccinate to yield AMP. Defects in the gene encoding ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency), an autosomal recessive disorder characterized by epilepsy, growth retardation and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adenylosuccinase; Adenylosuccinate lyase; adenylosuccinate lyase 1; ADSL; ASase; ASL
Gene Aliases: Adl; ADSL; AMPS; ASASE; ASL
UniProt ID: (Human) P30566, (Mouse) P54822
Entrez Gene ID: (Human) 158, (Mouse) 11564
purine nucleotide biosynthetic process
AMP biosynthetic process
'de novo' IMP biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
'de novo' AMP biosynthetic process
protein tetramerization
purine nucleotide metabolic process
response to nutrient
metabolic process
aerobic respiration
purine ribonucleotide biosynthetic process
ribonucleoside monophosphate biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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