Recommended positive controls: A431, H1299, HeLa, HepG2.
Predicted reactivity: Mouse (97%), Rat (95%), Zebrafish (84%), Xenopus laevis (90%), Pig (97%), Chicken (91%), Chimpanzee (98%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
ADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein that is involved in both purine biosynthesis and in the formation of adenosine monophosphate (AMP) from inosine monophosphate. Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis, namely the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and the subsequent removal of fumarate from adenylosuccinate to yield AMP. Defects in the gene encoding ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency), an autosomal recessive disorder characterized by epilepsy, growth retardation and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adenylosuccinase; Adenylosuccinate lyase; adenylosuccinate lyase 1; ADSL; ASase; ASL
Gene Aliases: Adl; ADSL; AMPS; ASASE; ASL
Molecular Function: lyase