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Proteintech
AFAP1L2 Polyclonal Antibody
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Product Details
17183-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AFAP1L2 Fusion Protein Ag10966 (466-818 aa encoded by BC033212)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SCIVSAAKN SLLLMQRKFS EPNTYIDGLP SQDRQEELYD DVDLSELTAA VEPTEEATPV ADDPNERESD RVYLDLTPVK SFLHGPSSAQ AQASSPTLSC LDNATEALPA DSGPGPTPDE PCIKCPENLG EQQLESLEPE DPSLRITTVK IQTEQQRISF PPSCPDAVVA TPPGASPPVK DRLRVTSAEI KLGKNRTEAE VKRYTEEKER LEKKKEEIRG HLAQLRKEKR ELKETLLKCT DKEVLASLEQ KLKEIDEECR GEESRRVDLE LSIMEVKDNL KKAEAGPVTL GTTVDTTHLE NVSPRPKAVT PASAPDCTPV NSATTLKNRP LSVVVTGKGT VLQKAKEWEK KGAS (466-818 aa encoded by B C033212)
Target Information
AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3beta, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: actin filament associated protein 1-like 2; Actin filament-associated protein 1-like 2; AFAP1-like protein 2; CTB-1144G6.6
Gene Aliases: AFAP1L2; AU041783; C86904; CTB-1144G6.4; KIAA1914; mKIAA1914; XB130
UniProt ID: (Human) Q8N4X5, (Mouse) Q5DTU0
Entrez Gene ID: (Human) 84632, (Mouse) 226250
inflammatory response
regulation of mitotic cell cycle
regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of transcription, DNA-templated
positive regulation of protein tyrosine kinase activity
regulation of signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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