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Alomone Labs, LTD
Frizzled-1 (FZD1) (extracellular) Polyclonal Antibody
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FIGURE: 1 / 2
Frizzled-1 (FZD1) (extracellular) Antibody (AFR-041-25UL) in WB
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4)kidney lysates: - 1,2. Anti-Frizzled-1 (FZD1) (extracellular) Antibody (#AFR-041), (1:200).3,4. Anti-Frizzled-1 (FZD1) (extracellular) Antibody , preincubated with Frizzled-1/FZD1 (extracellular) Blocking Peptide (#BLP-FR041).
Product Details
AFR-041-25UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)PEFWTSNPQHGGG, corresponding to amino acid residues 238-250 of rat Frizzled-1, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chfz-1; Dfrizzled-1; DKFZp564G072; Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 1; FLJ95923; frizzled; frizzled 1; frizzled 1, seven transmembrane spanning receptor; frizzled family receptor 1; frizzled homolog 1; frizzled, Drosophila, homolog of, 1; Frizzled-1; Fz receptor 1; Fz-1; FzE1; hFz1; mFz1; rFz1; unnamed protein product; Wnt receptor; Xfrizzled-1
Gene Aliases: AW227548; FZ-1; Fz1; FZD1
UniProt ID: (Human) Q9UP38, (Mouse) O70421
Entrez Gene ID: (Human) 8321, (Rat) 58868, (Mouse) 14362
transmembrane signaling receptor activity
G-protein coupled receptor activity
receptor binding
frizzled binding
protein binding
Wnt-protein binding
PDZ domain binding
Wnt-activated receptor activity
identical protein binding
protein homodimerization activity
protein heterodimerization activity
signal transducer activity
transmembrane signal receptor
membranous septum morphogenesis
muscular septum morphogenesis
outflow tract morphogenesis
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
cell-cell signaling
response to xenobiotic stimulus
positive regulation of neuron projection development
Wnt signaling pathway
neuron differentiation
negative regulation of BMP signaling pathway
autocrine signaling
non-canonical Wnt signaling pathway
astrocyte-dopaminergic neuron signaling
endothelial cell differentiation
positive regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
hard palate development
canonical Wnt signaling pathway
ventricular septum morphogenesis
negative regulation of canonical Wnt signaling pathway
presynapse assembly
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
midbrain dopaminergic neuron differentiation
regulation of presynapse assembly
regulation of mesenchymal stem cell differentiation
positive regulation of protein phosphorylation
epithelial cell differentiation
negative regulation of catenin import into nucleus
response to drug
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
canonical Wnt signaling pathway involved in osteoblast differentiation
regulation of osteoblast differentiation
lung alveolus development
positive regulation of sequence-specific DNA binding transcription factor activity
cellular response to vitamin D
cellular response to growth factor stimulus
cellular response to peptide hormone stimulus
planar cell polarity pathway involved in neural tube closure
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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