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Product Details
16346-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AGER Fusion Protein Ag9540 (26-340 aa encoded by BC020669)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ITARIGEPL VLKCKGAPKK PPQRLEWKLN TGRTEAWKVL SPQGGGPWDS VARVLPNGSL FLPAVGIQDE GIFRCQAMNR NGKETKSNYR VRVYQIPGKP EIVDSASELT AGVPNKVGTC VSEGSYPAGT LSWHLDGKPL VPNEKGVSVK EQTRRHPETG LFTLQSELMV TPARGGDPRP TFSCSFSPGL PRHRALRTAP IQPRVWEPVP LEEVQLVVEP EGGAVAPGGT VTLTCEVPAQ PSPQIHWMKD GVPLPLPPSP VLILPEIGPQ DQGTYSCVAT HSSHGPQESR AVSISIIEPG EEGPTAGSVG GSGLGT (26-340 aa encoded by BC020669)
Target Information
The Receptor for Advanced Glycation End-products (RAGE) is a gene located on human chromosome 6p21.3, encoding a transmembrane receptor belonging to the immunoglobulin superfamily. RAGE is expressed in various tissues, with significant levels in the lungs, and plays a crucial role in cellular signaling and inflammation. As a receptor, RAGE binds multiple ligands, including advanced glycation end-products (AGEs), amyloid-ß peptide, high mobility group box 1 (HMGB1), and S100/calgranulin proteins, facilitating diverse pathological processes like inflammation, cancer progression, and neurodegeneration. The interaction between RAGE and its ligands triggers intracellular signaling pathways such as NF-?B activation, leading to inflammatory responses and oxidative stress. In the context of chronic diseases like diabetes, Alzheimer's, and cardiovascular diseases, RAGE is a critical mediator, linking metabolic disturbance to cellular dysfunction. Therapeutic targeting of RAGE signaling is under investigation, aiming to mitigate its contribution to inflammatory and degenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: advanced glycation end-products receptor; Advanced glycosylation end product-specific receptor; advanced glycosylation end product-specific receptor variant 2; advanced glycosylation end product-specific receptor variant 3; advanced glycosylation end product-specific receptor variant 4; advanced glycosylation end product-specific receptor variant 5; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; RAGE-4 ORF3; receptor for advanced glycation end-products variant 20; Receptor for advanced glycosylation end products; sRAGE
Gene Aliases: AGER; RAGE; SCARJ1
UniProt ID: (Human) Q15109, (Mouse) Q62151
Entrez Gene ID: (Human) 177, (Rat) 81722, (Mouse) 11596
regulation of T cell mediated cytotoxicity
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
inflammatory response
negative regulation of cell adhesion
cell surface receptor signaling pathway
JAK-STAT cascade
brain development
glycoprotein metabolic process
response to wounding
response to fructose
positive regulation of autophagy
negative regulation of endothelial cell migration
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
positive regulation of fibroblast migration
response to activity
positive regulation of smooth muscle cell migration
lung development
neuron projection development
negative regulation of interleukin-10 production
positive regulation of interleukin-12 production
negative regulation of collagen biosynthetic process
response to vitamin A
response to genistein
negative regulation of osteoblast proliferation
cellular response to drug
positive regulation of activated T cell proliferation
positive regulation of neuron apoptotic process
innate immune response
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
positive regulation of NF-kappaB transcription factor activity
response to methylglyoxal
calcium ion homeostasis
response to hyperoxia
positive regulation of phagocytosis, engulfment
transdifferentiation
cellular response to hydrogen peroxide
cellular response to glucose stimulus
cellular response to fatty acid
cellular response to organic cyclic compound
response to selenite ion
positive regulation of potassium ion transmembrane transporter activity
positive regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
regulation of CD4-positive, alpha-beta T cell activation
positive regulation of type B pancreatic cell apoptotic process
positive regulation of dendritic cell differentiation
response to hypoxia
positive regulation of cell migration
positive regulation of apoptotic process
positive regulation of JUN kinase activity
regulation of inflammatory response
induction of positive chemotaxis
regulation of DNA binding
protein localization to membrane
positive regulation of neuron death
Performance Guarantee
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