Proteintech

AGGF1 Polyclonal Antibody

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AGGF1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human spleen using 11889-1-AP (AGGF1 antibody) at dilution of 1:25 (under 10x lens).

AGGF1 Antibody in Western Blot (WB) — Mouse liver tissue were subjected to SDS PAGE followed by western blot with 11889-1-AP (AGGF1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

11889-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 8 publications 8 publications
Immunohistochemistry (IHC)	-	View 4 publications 4 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:10-1:100	-
Immunocytochemistry (ICC/IF)	-	View 1 publication 1 publication
Miscellaneous PubMed (Misc)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	AGGF1 Fusion Protein Ag2497 (442-707 aa encoded by BC029382) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.27 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

11889-1-AP was validated by KO and KD methods and the observed MW is 84 kDa.

Immunogen sequence: DMEHTLRIP EVGVSKFHAE IYFDHDLQSY VPVDQGSQNG TIVNGKQILQ PKTKCDPYVL EHGDEVKIGE TVLSFHIHPG SDTCDGCEPG QVRAHLRLDK KDESFVGPTL SKEEKELERR KELKKIRVKY GLQNTEYEDE KTLKNPKYKD RAGKRREQVG SEGTFQRDDA PASVHSEITD SNKGRKMLEK MGWKKGEGLG KDGGGMKTPI QLQLRRTHAG LGTGKPSSFE DVHLLQNKNK KNWDKARERF TENFPETKPQ KDDPGTMP (442-707 aa encoded by BC029382)

Target Information

VG5Q (Aggf1) gene encodes an angiogenic factor that promotes proliferation of endothelial cells. Mutations in this gene are associated with a susceptibility to Klippel-Trenaunay syndrome. Pseudogenes of this gene are found on chromosomes 3, 4, 10 and 16.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The Effect of MCM3AP-AS1/miR-211/KLF5/AGGF1 Axis Regulating Glioblastoma Angiogenesis.

Frontiers in molecular neuroscience

Yang C,Zheng J,Xue Y,Yu H,Liu X,Ma J,Liu L,Wang P,Li Z,Cai H,Liu Y

Wed Sep 30 00:00:00 EDT 2020

Angiotensin II increases angiogenesis by NF-κB-mediated transcriptional activation of angiogenic factor AGGF1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Si W,Xie W,Deng W,Xiao Y,Karnik SS,Xu C,Chen Q,Wang QK

Sat Sep 01 00:00:00 EDT 2018

circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways.

Molecular therapy. Nucleic acids

He Q,Zhao L,Liu Y,Liu X,Zheng J,Yu H,Cai H,Ma J,Liu L,Wang P,Li Z,Xue Y

Fri Mar 02 00:00:00 EST 2018

A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure.

Nature communications

Yao Y,Lu Q,Hu Z,Yu Y,Chen Q,Wang QK

Tue Jul 25 00:00:00 EDT 2017

A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure.

Nature communications

Yao Y,Lu Q,Hu Z,Yu Y,Chen Q,Wang QK

Tue Jul 25 00:00:00 EDT 2017

Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury.

Journal of the American Heart Association

Yao Y,Hu Z,Ye J,Hu C,Song Q,Da X,Yu Y,Li H,Xu C,Chen Q,Wang QK

Sun Jun 25 00:00:00 EDT 2017

Angiogenic Factor With G Patch and FHA Domains 1 Is a Novel Regulator of Vascular Injury.

Arteriosclerosis, thrombosis, and vascular biology

Zhou B,Zeng S,Li N,Yu L,Yang G,Yang Y,Zhang X,Fang M,Xia J,Xu Y

Sat Apr 01 00:00:00 EDT 2017

Angiogenic Factor With G Patch and FHA Domains 1 Is a Novel Regulator of Vascular Injury.

Arteriosclerosis, thrombosis, and vascular biology

Zhou B,Zeng S,Li N,Yu L,Yang G,Yang Y,Zhang X,Fang M,Xia J,Xu Y

Sat Apr 01 00:00:00 EDT 2017

Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease.

PLoS biology

Lu Q,Yao Y,Hu Z,Hu C,Song Q,Ye J,Xu C,Wang AZ,Chen Q,Wang QK

Mon Aug 01 00:00:00 EDT 2016

Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF-β signaling.

Biochimica et biophysica acta

Zhou B,Zeng S,Li L,Fan Z,Tian W,Li M,Xu H,Wu X,Fang M,Xu Y

Wed Jun 01 00:00:00 EDT 2016

Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma.

Biochimica et biophysica acta

Xu Y,Zhou M,Wang J,Zhao Y,Li S,Zhou B,Su Z,Xu C,Xia Y,Qian H,Tu X,Xiao W,Chen X,Chen Q,Wang QK

Thu May 01 00:00:00 EDT 2014

Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma.

Biochimica et biophysica acta

Xu Y,Zhou M,Wang J,Zhao Y,Li S,Zhou B,Su Z,Xu C,Xia Y,Qian H,Tu X,Xiao W,Chen X,Chen Q,Wang QK

Thu May 01 00:00:00 EDT 2014

Angiogenic factor AGGF1 promotes therapeutic angiogenesis in a mouse limb ischemia model.

PloS one

Lu Q,Yao Y,Yao Y,Liu S,Huang Y,Lu S,Bai Y,Zhou B,Xu Y,Li L,Wang N,Wang L,Zhang J,Cheng X,Qin G,Ma W,Xu C,Tu X,Wang Q

Wed Apr 17 00:00:00 EDT 2013

Angiogenic factor AGGF1 promotes therapeutic angiogenesis in a mouse limb ischemia model.

PloS one

Lu Q,Yao Y,Yao Y,Liu S,Huang Y,Lu S,Bai Y,Zhou B,Xu Y,Li L,Wang N,Wang L,Zhang J,Cheng X,Qin G,Ma W,Xu C,Tu X,Wang Q

Wed Apr 17 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: Angiogenic factor VG5Q; Angiogenic factor with G patch and FHA domains 1; FLJ10283; G patch domain-containing protein 7; hVG5Q; mVG5Q; Vasculogenesis gene on 5q protein

Gene Aliases: 2010009L17Rik; 2310029P06Rik; AGGF1; AW112072; GPATC7; GPATCH7; HSU84971; HUS84971; Peg3; RGD1310888; VG5Q

UniProt ID: (Human) Q8N302, (Mouse) Q7TN31

Entrez Gene ID: (Human) 55109, (Mouse) 66549, (Rat) 310005

Molecular Function: DNA-binding transcription factor gene-specific transcriptional regulator