Recommended positive controls: A431, H1299, mouse heart.
Predicted reactivity: Mouse (97%), Rat (96%), Pig (95%), Rhesus Monkey (99%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Acylglycerol kinase, mitochondrial; FLJ10842; hAGK; HsMuLK; MuLK; multi-substrate lipid kinase; Multiple substrate lipid kinase
Gene Aliases: 2610037M15Rik; 6720408I04Rik; AGK; AI465370; CATC5; CTRCT38; MTDPS10; MULK
Molecular Function: kinase