Immunogen sequence: LHLSGMDVTI VKTDYEGQAK KLLELMENTD VIIVAGGDGT LQEVVTGVLR RTDEATFSKI PIGFIPLGET SSLSHTLFAE SGNKV
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.
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Protein Aliases: Acylglycerol kinase, mitochondrial; FLJ10842; hAGK; HsMuLK; multi-substrate lipid kinase; Multiple substrate lipid kinase
Gene Aliases: AGK; CATC5; CTRCT38; MTDPS10; MULK
UniProt ID: (Human) Q53H12
Entrez Gene ID: (Human) 55750
Molecular Function: kinase