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Invitrogen
AGPAT2 Polyclonal Antibody
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Product Details
PA5-112352
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human 1-acyl-sn-glycerol-3-phosphate acyltransferase beta protein (199-278AA)
Conjugate
Form
Liquid
Concentration
0.55 mg/mL
Amount
55 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Lysophospholipid acyltransferases (LPLATs) catalyse the addition of fatty acyl moieties to the glycerol backbone of lysophospholipids. In addition to playing a crutial role in the synthesis of structural membrane components the LPLATs are also implicated in cellular signalling responses for cytokines, growth factors and other agonists. Cellular signalling through the interleukin 1 receptor in human mesangial cells and EL-4 cells proceeds by the activation of lysophosphatidic acid acyltransferase (LPAAT). Activation of LPAAT by interleukin 1 results in the generation of unsaturated phosphatidic acid species, that are crucial to the generation of diacylglycerol and interleukin 1 signalling. LPLATs are also involved in signalling for increased interleukin 2 synthesis through the T cell antigen receptor. Activation of T-cells via anti-CD3 stimulation has been shown to increase incorporation of polyunsaturated fatty acids intophosphatidylcholine via lysophosphatidylcholine acyltransferase.Activation of this enzyme is essential for the sustained activationand translocation of protein kinase C.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-acylglycerol-3-phosphate O-acyltransferase 2; 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta); 1-AGP acyltransferase 2; LPAAT-beta; Lysophosphatidic acid acyltransferase beta; lysophosphatidic acid acyltransferase-beta; lysophospholipid acyltransferase 2; testicular tissue protein Li 143
Gene Aliases: 1-AGPAT2; AGPAT2; BSCL; BSCL1; LPAAB; LPAAT-beta; LPLAT2
UniProt ID: (Human) O15120
Entrez Gene ID: (Human) 10555
positive regulation of cytokine production
positive regulation of cytokine-mediated signaling pathway
lipid metabolic process
phospholipid metabolic process
phosphatidic acid biosynthetic process
epidermis development
phospholipid biosynthetic process
response to xenobiotic stimulus
CDP-diacylglycerol biosynthetic process
triglyceride biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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