Immunogen sequence: QIELTGKRYP LSGMGLPTFK EWIQNTLGVN VEHKTTSKAS LNPSDTPPSV VNEDFLHDLK ETNISYSQEA DDRVFRAHGH CLH
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 81%.
This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome.
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Protein Aliases: ADAP-S; ADAS; ADHAPS; ADPS; Aging-associated gene 5 protein; aging-associated protein 5; ALDHPSY; Alkyl-DHAP synthase; alkyldihydroxyacetonephosphate synthase; Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkylglycerone-phosphate synthase; peroxisomal
Gene Aliases: AAG5; ADAP-S; ADAS; ADHAPS; ADPS; AGPS; ALDHPSY; RCDP3
UniProt ID: (Human) O00116
Entrez Gene ID: (Human) 8540