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Alomone Labs, LTD

Ghrelin Receptor (GHSR) (extracellular) Polyclonal Antibody

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Ghrelin Receptor (GHSR) (extracellular) Polyclonal Antibody

Product Details

AGR-031-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (IHC)

1:800
-

Immunocytochemistry (ICC/IF)

1:50
-

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CRATEFAVRSG, corresponding to amino acid residues 197-207 of rat Ghrelin receptor, 2nd extracellular loop
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

200 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Growth hormone secretagogue receptor 1a (GHSR) is a member of the G-protein coupled receptor family. GHSR may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations to the gene can cause isolated partial growth hormone deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: G-protein coupled receptor; GH-releasing peptide receptor; Ghrelin receptor; GHRP; Ghrp receptor; GHS receptor; GHS-R; Growth hormone secretagogue receptor type 1

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Gene Aliases: C530020I22Rik; GHDP; GHS-R1a; GHSR; GHSR-1a

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UniProt ID: (Human) Q92847, (Mouse) Q99P50, (Rat) O08725

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Entrez Gene ID: (Human) 2693, (Mouse) 208188, (Rat) 84022

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Function(s)
growth hormone secretagogue receptor activity G-protein coupled receptor activity protein binding growth hormone-releasing hormone receptor activity peptide hormone binding hormone binding identical protein binding signal transducer activity growth hormone receptor binding G-protein coupled receptor
Process(es)
G-protein coupled receptor internalization signal transduction G-protein coupled receptor signaling pathway spermatogenesis female pregnancy learning or memory actin polymerization or depolymerization adult feeding behavior response to hormone hormone-mediated signaling pathway negative regulation of norepinephrine secretion peptide hormone secretion growth hormone secretion response to food negative regulation of appetite positive regulation of appetite response to follicle-stimulating hormone response to estradiol negative regulation of interleukin-1 beta production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production cellular response to insulin stimulus cellular response to hormone stimulus ghrelin secretion positive regulation of multicellular organism growth regulation of hindgut contraction positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of fatty acid metabolic process positive regulation of growth negative regulation of insulin secretion decidualization insulin-like growth factor receptor signaling pathway negative regulation of inflammatory response regulation of synapse assembly regulation of transmission of nerve impulse regulation of growth hormone secretion regulation of feeding behavior response to growth hormone cellular response to lipopolysaccharide response to dexamethasone negative regulation of locomotion involved in locomotory behavior cellular response to thyroid hormone stimulus regulation of neurotransmitter receptor localization to postsynaptic specialization membrane postsynaptic modulation of chemical synaptic transmission regulation of postsynapse organization positive regulation of small intestinal transit response to L-glutamate positive regulation of sprouting angiogenesis positive regulation of eating behavior positive regulation of small intestine smooth muscle contraction regulation of gastric motility positive regulation of vascular endothelial cell proliferation cellular response to insulin-like growth factor stimulus negative regulation of macrophage apoptotic process negative regulation of tumor necrosis factor biosynthetic process negative regulation of interleukin-6 biosynthetic process
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