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Proteintech
AGR2 Polyclonal Antibody
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Product Details
12275-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AGR2 Fusion Protein Ag2919 (37-195 aa encoded by BC015503)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YTLARDTTV KPGAKKDTKD SRPKLPQTLS RGWGDQLIWT QTYEEALYKS KTSNKPLMII HHLDECPHSQ ALKKVFAENK EIQKLAEQFV LLNLVYETTD KHLSPDGQYV PRIMFVDPSL TVRADITGRY SNRLYAYEPA DTALLLDNMK KALKLLKTEL (37-195 aa encoded by BC015503)
Target Information
AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. They are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours. AGR2 is ubiquitously expressed with upregulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AG-2; AGR2 SV-C; anterior gradient 2 homolog; anterior gradient homolog 2; Anterior gradient protein 2 homolog; epididymis secretory protein Li 116; HPC8; protein disulfide isomerase family A, member 17; Protein Gob-4; secreted cement gland homolog; Secreted cement gland protein XAG-2 homolog; unnamed protein product
Gene Aliases: AG-2; AG2; AGR2; Agr2h; GOB-4; Gob4; HAG-2; HEL-S-116; HPC8; mAG-2; PDIA17; RIFTD; UNQ515/PRO1030; XAG-2
UniProt ID: (Human) O95994, (Mouse) O88312
Entrez Gene ID: (Human) 10551, (Mouse) 23795, (Rat) 298961
inflammatory response
positive regulation of gene expression
positive regulation of cell-substrate adhesion
response to endoplasmic reticulum stress
positive regulation of epidermal growth factor receptor signaling pathway
digestive tract morphogenesis
positive regulation of developmental growth
lung goblet cell differentiation
mucus secretion
positive regulation of protein localization to plasma membrane
positive regulation of IRE1-mediated unfolded protein response
positive regulation of PERK-mediated unfolded protein response
negative regulation of cell death
positive regulation of establishment of protein localization to plasma membrane
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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