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Invitrogen
AGR2 Polyclonal Antibody
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FIGURE: 1 / 4
AGR2 Antibody (PA5-85636) in ICC/IF
AGR2 antibody detects AGR2 protein at cytoplasm by immunofluorescent analysis. Sample: MCF7 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: AGR2 protein stained by AGR2 antibody (Product # PA5-85636) diluted at 1:1,000. Blue: Hoechst 33342 staining. Scale bar = 10 μm.
Product Details
PA5-85636
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human Anterior Gradient 2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.203 mg/mL
Amount
20.3 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (93%), Rat (93%), Zebrafish (82%), Pig (96%), Rhesus Monkey (99%), Bovine (95%).
Positive Control: MCF-7.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. They are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours. AGR2 is ubiquitously expressed with upregulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AG-2; AGR2 SV-C; anterior gradient 2 homolog; anterior gradient homolog 2; Anterior gradient protein 2 homolog; epididymis secretory protein Li 116; HPC8; protein disulfide isomerase family A, member 17; Protein Gob-4; secreted cement gland homolog; Secreted cement gland protein XAG-2 homolog; unnamed protein product
Gene Aliases: AG-2; AG2; AGR2; Agr2h; GOB-4; Gob4; HAG-2; HEL-S-116; HPC8; mAG-2; PDIA17; RIFTD; UNQ515/PRO1030; XAG-2
UniProt ID: (Human) O95994, (Mouse) O88312
Entrez Gene ID: (Human) 10551, (Mouse) 23795
inflammatory response
positive regulation of gene expression
positive regulation of cell-substrate adhesion
response to endoplasmic reticulum stress
positive regulation of epidermal growth factor receptor signaling pathway
digestive tract morphogenesis
positive regulation of developmental growth
lung goblet cell differentiation
mucus secretion
positive regulation of protein localization to plasma membrane
positive regulation of IRE1-mediated unfolded protein response
positive regulation of PERK-mediated unfolded protein response
negative regulation of cell death
positive regulation of establishment of protein localization to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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