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          • Primary Antibodies ›
          • Angiotensinogen Antibodies

          Bioss

          AGT Polyclonal Antibody

          View all (21) Angiotensinogen antibodies

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          Cite AGT Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          AGT Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          AGT Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          AGT Antibody (BS-0045M) in IHC (P)

          Formalin-fixed and paraffin embedded rat liver labeled with Anti AGT Polyclonal Antibody,Unconjugated (bs-0045M) at 1:200 followed by conjugation to the secondary antibody and DAB staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          AGT Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          AGT Polyclonal Antibody

          Product Details

          BS-0045M

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -
          Product Specifications

          Species Reactivity

          Human, Rat

          Host/Isotype

          Mouse / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from rat AGT, amino acids 51-110.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; Angiotensinogen; angiotensinogen (PAT); fetal-liver predominant transporter 1; pre-angiotensinogen; preangiotensinogen; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8; unnamed protein product

          View more View less

          Gene Aliases: AGT; Ang; AngII; ANHU; ANRT; hFLT1; PAT; SERPINA8

          View more View less

          UniProt ID: (Human) P01019, (Rat) P01015

          View more View less

          Entrez Gene ID: (Human) 183, (Rat) 24179

          View more View less

          Function(s)
          serine-type endopeptidase inhibitor activity hormone activity protein binding growth factor activity superoxide-generating NADPH oxidase activator activity sodium channel regulator activity type 1 angiotensin receptor binding type 2 angiotensin receptor binding receptor agonist activity angiotensin receptor binding protease inhibitor
          Process(es)
          regulation of cell growth positive regulation of cytokine production kidney development blood vessel remodeling regulation of blood volume by renin-angiotensin renin-angiotensin regulation of aldosterone production regulation of renal output by angiotensin regulation of blood vessel size by renin-angiotensin renal system process regulation of systemic arterial blood pressure by renin-angiotensin G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger phospholipase C-activating G-protein coupled receptor signaling pathway cell-cell signaling regulation of blood pressure positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy negative regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of macrophage derived foam cell differentiation response to muscle activity involved in regulation of muscle adaptation regulation of vasoconstriction positive regulation of superoxide anion generation low-density lipoprotein particle remodeling regulation of renal sodium excretion nitric oxide-cGMP-mediated signaling pathway angiotensin-activated signaling pathway regulation of cell proliferation vasoconstriction regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of MAP kinase activity positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of fibroblast proliferation positive regulation of inflammatory response negative regulation of neurotrophin TRK receptor signaling pathway positive regulation of protein kinase B signaling renal sodium ion absorption positive regulation of branching involved in ureteric bud morphogenesis positive regulation of cholesterol metabolic process regulation of blood vessel diameter positive regulation of angiotensin-activated signaling pathway regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly negative regulation of sodium ion transmembrane transport positive regulation of membrane hyperpolarization positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of gap junction assembly regulation of cardiac conduction response to angiotensin positive regulation of reactive oxygen species metabolic process positive regulation of extrinsic apoptotic signaling pathway ovarian follicle rupture blood vessel development branching involved in ureteric bud morphogenesis regulation of systemic arterial blood pressure by circulatory renin-angiotensin angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure brain renin-angiotensin system angiotensin-mediated drinking behavior positive regulation of extracellular matrix constituent secretion cellular sodium ion homeostasis cell-matrix adhesion cell surface receptor signaling pathway activation of phospholipase C activity activation of NF-kappaB-inducing kinase activity female pregnancy aging excretion establishment of blood-nerve barrier positive regulation of cell proliferation negative regulation of cell proliferation response to cold response to salt stress regulation of gene expression positive regulation of activation of JAK2 kinase activity positive regulation of gene expression positive regulation of cholesterol esterification negative regulation of endopeptidase activity regulation of norepinephrine secretion positive regulation of phosphatidylinositol 3-kinase signaling artery smooth muscle contraction negative regulation of angiogenesis extracellular matrix organization negative regulation of cell growth peristalsis positive regulation of cellular protein metabolic process positive regulation of peptidyl-serine phosphorylation negative regulation of tissue remodeling catenin import into nucleus positive regulation of renal sodium excretion positive regulation of multicellular organism growth vasodilation hormone metabolic process drinking behavior positive regulation of catalytic activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of fatty acid biosynthetic process positive regulation of blood pressure positive regulation of vasodilation positive regulation of organ growth astrocyte activation fibroblast proliferation regulation of long-term neuronal synaptic plasticity smooth muscle cell proliferation cytokine secretion regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation smooth muscle cell differentiation stress-activated MAPK cascade regulation of calcium ion transport regulation of transmission of nerve impulse cell growth involved in cardiac muscle cell development positive regulation of protein tyrosine kinase activity ERK1 and ERK2 cascade uterine smooth muscle contraction cellular response to mechanical stimulus positive regulation of protein kinase C activity
          It has to be done as per old AB suggested Products section.

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