A suggested positive control is mouse liver tissue lysate.
PA5-20813 can be used with blocking peptide PEP-0927.
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.
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Protein Aliases: angiotensin II receptor, type 2; angiotensin II type 2 receptor; Angiotensin II type-2 receptor; angiotensin receptor 2; AT2; AT2 receptor; AT2, ATGR2, MRX88; Type-2 angiotensin II receptor
Gene Aliases: AGTR2; AI316812; AT2; AT2-R; AT2R; AT2R; ATGR2; AW107640; MRX88