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Product Details
PA5-33341
Product Specifications
Species Reactivity
Bat,
Bovine,
Dog,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Sheep,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from internal region of human AGTR2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550723
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Sheep, Dog, Bat, Bovine, Hamster, Elephant, Panda, Horse, Pig (100%).
For IHC(P), use proteinase K antigen retrieval. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Angiotensin ii at2; angiotensin II receptor, type 2; angiotensin II subtype 2 receptor, AT2; angiotensin II type 2 receptor; Angiotensin II type-2 receptor; angiotensin receptor 2; angiotensin type II receptor; AT2; AT2 receptor; Type-2 angiotensin II receptor; type-2 angiotensin II receptor-like protein
Gene Aliases: AGTR2; AI316812; AT2; AT2-R; AT2R; AT2R; ATGR2; AW107640; MRX88
UniProt ID: (Human) P50052, (Sheep) Q28929, (Rat) P35351, (Mouse) P35374
blood vessel remodeling
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
renin-angiotensin regulation of aldosterone production
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
brain renin-angiotensin system
cellular sodium ion homeostasis
inflammatory response
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
nitric oxide mediated signal transduction
brain development
regulation of blood pressure
positive regulation of cell proliferation
negative regulation of heart rate
negative regulation of norepinephrine secretion
cerebellar cortex development
negative regulation of cell growth
negative regulation of icosanoid secretion
positive regulation of phosphoprotein phosphatase activity
intracellular signal transduction
regulation of metanephros size
exploration behavior
positive regulation of renal sodium excretion
aldosterone secretion
angiotensin-activated signaling pathway
dopamine biosynthetic process
regulation of transcription factor import into nucleus
negative regulation of blood vessel endothelial cell migration
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
negative regulation of fibroblast proliferation
positive regulation of cytokine secretion
positive regulation of nitric-oxide synthase activity
negative regulation of neurotrophin TRK receptor signaling pathway
cell growth involved in cardiac muscle cell development
cellular response to dexamethasone stimulus
positive regulation of metanephric glomerulus development
positive regulation of branching involved in ureteric bud morphogenesis
extracellular negative regulation of signal transduction
positive regulation of extrinsic apoptotic signaling pathway
kidney development
response to organonitrogen compound
neuron differentiation
negative regulation of neuron apoptotic process
kidney morphogenesis
signal transduction
regulation of vasodilation
regulation of apoptotic process
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