Immunogen sequence: DSVASLGGTP LYMDRQGIDI LYSGSQKALN APPGTSLISF SDKAKKKMYS RKTKPFSFYL DIKWLANFWG CDDQPRMYHH TIPVISLYSL RESLALIAEQ GLENSWRQHR EAAAYLHGRL QALGLQLFVK DPALRLPTVT TVAVPAGYDW RDIVSYVIDH FDIEIMGGLG PSTGKVLRIG LLGCNATREN VDRVTEALRA ALQHCPKKKL; Positive Samples: LO2, 293T; Cellular Location: Mitochondrion, Peroxisome
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targeting, have been associated with type I primary hyperoxaluria.
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Protein Aliases: AGT; Alanine--glyoxylate aminotransferase; hepatic peroxisomal alanine:glyoxylate aminotransferase; L-alanine: glyoxylate aminotransferase 1; Serine--pyruvate aminotransferase; serine-pyruvate aminotransferase; serine:pyruvate aminotransferase; SPT
Gene Aliases: AGT; AGT1; AGXT; AGXT1; PH1; SPAT; SPT; TLH6
UniProt ID: (Human) P21549
Entrez Gene ID: (Human) 189