This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria.
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Protein Aliases: AGT; AGT1; AGXT1; Alanine--glyoxylate aminotransferase; alanine-glyoxylate aminotransferase 1; angiotensin receptor 2; hepatic peroxisomal alanine:glyoxylate aminotransferase; L-alanine: glyoxylate aminotransferase 1; PH1; Serine--pyruvate aminotransferase; Serine--pyruvate aminotransferase, mitochondrial; serine--pyruvate aminotransferase, peroxisomal; serine-pyruvate aminotransferase; serine:pyruvate aminotransferase; serine:pyruvate aminotransferase SPT; serine:pyruvate/alanine:glyoxylate aminotransferase; SPAT; SPT; TLH6
Gene Aliases: AGT; AGT1; AGXT; AGXT1; PH1; SPAT; SPT; TLH6