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Invitrogen
AID Polyclonal Antibody
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Product Details
PA5-86823
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in Human AICDA
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activation induced deaminase; Activation-induced cytidine deaminase; AID; AID isoform AIDins(IVS3); Cytidine aminohydrolase; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; Single-stranded DNA cytosine deaminase
Gene Aliases: AICDA; AID; ARP2; CDA2; HEL-S-284; HIGM2
UniProt ID: (Human) Q9GZX7, (Mouse) Q9WVE0
Entrez Gene ID: (Human) 57379, (Mouse) 11628, (Rat) 399679
RNA binding
catalytic activity
cytidine deaminase activity
protein binding
zinc ion binding
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
ubiquitin protein ligase binding
identical protein binding
metal ion binding
molecular_function
RNA processing factor
mRNA processing
regulation of macromolecule biosynthetic process
somatic diversification of immunoglobulins
somatic hypermutation of immunoglobulin genes
cytidine to uridine editing
B cell differentiation
regulation of nuclear cell cycle DNA replication
defense response to bacterium
hypomethylation of CpG island
isotype switching
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
defense response to virus
DNA cytosine deamination
cellular response to lipopolysaccharide
cytidine deamination
DNA demethylation
negative regulation of methylation-dependent chromatin silencing
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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