AIDA acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AIDA; Axin interaction partner and dorsalization antagonist; Axin interactor, dorsalization-associated protein; C1orf80; RP11 378J18.7
Gene Aliases: 2610208M17Rik; AIDA; BC004835; C1orf80