AIDA acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.
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Protein Aliases: Axin interaction partner and dorsalization antagonist; Axin interactor, dorsalization-associated protein
Gene Aliases: 2610208M17Rik; AIDA; BC004835; C1orf80