Peptide sequence: EMKYTSEGVR YFVDHNTRTT TFKDPRPGFE SGTKQGSPGA YDRSFRWKYH
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 93%; Sheep: 100%; Zebrafish: 80%
This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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Protein Aliases: AIP2; atrophin-1 interacting protein 2; Atrophin-1-interacting protein 2; HECT-type E3 ubiquitin transferase WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2; WW domain-containing protein 2
Gene Aliases: AIP2; WWP2; WWp2-like
UniProt ID: (Human) F5H213
Entrez Gene ID: (Human) 11060
Molecular Function: ubiquitin-protein ligase