Bioss

AKAP6 Polyclonal Antibody

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AKAP6 Polyclonal Antibody

Product Details

BS-7904R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human AKAP6, amino acids 1451-1650.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A kinase (PRKA) anchor protein 6; A-kinase anchor protein 100 kDa; A-kinase anchor protein 6; A-kinase anchoring protein alpha; A-kinase anchoring protein beta; AKAP 100; AKAP-6; anchor protein 6; mAKAP; PRKA6; protein kinase A anchoring protein 6; Protein kinase A-anchoring protein 6

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Gene Aliases: ADAP100; ADAP6; AI482140; AKAP100; AKAP6; Akapalpha; Akapbeta; KIAA0311; mAKAP; PRKA; PRKA6

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UniProt ID: (Human) Q13023, (Rat) Q9WVC7

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Entrez Gene ID: (Human) 9472, (Mouse) 238161, (Rat) 64553

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Function(s)
protein binding adenylate cyclase binding protein complex scaffold protein kinase A regulatory subunit binding protein anchor ion channel binding protein kinase A binding enzyme binding protein N-terminus binding protein phosphatase 2A binding kinase activity
Process(es)
positive regulation of protein phosphorylation regulation of protein kinase A signaling positive regulation of cell growth negative regulation of cAMP biosynthetic process positive regulation of protein phosphatase type 2B activity cellular protein complex localization positive regulation of release of sequestered calcium ion into cytosol positive regulation of NFAT protein import into nucleus regulation of membrane repolarization positive regulation of ryanodine-sensitive calcium-release channel activity positive regulation of cell growth involved in cardiac muscle cell development positive regulation of calcineurin-NFAT signaling cascade cellular response to cAMP cellular response to cytokine stimulus cellular response to epinephrine stimulus regulation of cardiac muscle cell contraction positive regulation of potassium ion transmembrane transport regulation of relaxation of cardiac muscle positive regulation of delayed rectifier potassium channel activity positive regulation of cAMP-dependent protein kinase activity action potential protein targeting regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum cAMP-mediated signaling intracellular signal transduction phosphorylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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