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Product Details
PA5-61811
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human AKAP6. Recombinant protein control fragment (Product #RP-103035).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2637813
Product Specific Information
Immunogen sequence: SHSATKSALI QKLMQDIQHQ DNYEAIWEKI EGFVNKLDEF IQWLNEAMET TENWTPPKAE MDDLKLYLET HLSFKLNVDS HCALKEAVEE EGHQLLELIA SHKAGLKDML RMIASQWKEL QRQIKRQHSW ILRALDTIKA
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 93%.
Target Information
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A kinase (PRKA) anchor protein 6; A-kinase anchor protein 100 kDa; A-kinase anchor protein 6; AKAP 100; AKAP-6; mAKAP; PRKA6; protein kinase A anchoring protein 6; Protein kinase A-anchoring protein 6
Gene Aliases: ADAP100; ADAP6; AKAP100; AKAP6; KIAA0311; mAKAP; PRKA6
UniProt ID: (Human) Q13023
Entrez Gene ID: (Human) 9472
action potential
protein targeting
regulation of protein kinase A signaling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
cAMP-mediated signaling
positive regulation of cell growth
negative regulation of cAMP biosynthetic process
positive regulation of protein phosphatase type 2B activity
intracellular signal transduction
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of NFAT protein import into nucleus
regulation of membrane repolarization
positive regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of cell growth involved in cardiac muscle cell development
positive regulation of calcineurin-NFAT signaling cascade
cellular response to cAMP
cellular response to cytokine stimulus
positive regulation of potassium ion transmembrane transport
positive regulation of delayed rectifier potassium channel activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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