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Product Details
PA5-120850
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 480-692 of human AKAP8 (NP_005849.1).
Conjugate
Form
Liquid
Concentration
1.08 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914422
Product Specific Information
Positive test controls include: LO2, 293T, BxPC-3, HeLa, Jurkat, mouse thymus. The target is usually found in the following locations: Nucleus matrix.^M
^M
Immunogen sequence: HCLACDMLIP AQPQLLQRHL HSVDHNHNRR LAAEQFKKTS LHVAKSVLNN RHIVKMLEKY LKGEDPFTSE TVDPEMEGDD NLGGEDKKET PEEVAADVLA EVITAAVRAV DGEGAPAPES SGEPAEDEGP TDTAEAGSDP QAEQLLEEQV PCGTAHEKGV PKARSEAAEA GNGAETMAAE AESAQTRVAP APAAADAEVE QTDAESKDAV PTE
Target Information
The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 95, also known as AKAP 8, is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney and skeletal muscle. During mitosis, AKAP 95 is recruited to the chromosomes and plays an essential role in mitotic progression. Characteristic of its family, AKAP 95 participates in PKA signaling through an interaction with the RII regulatory subunit. In addition, AKAP 95 forms a complex with HA95 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A kinase (PRKA) anchor protein 8; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; AKAP 8; AKAP 95; AKAP-8; DKFZp586B1222
Gene Aliases: 1200016A02Rik; AA673585; AKAP 95; AKAP-8; AKAP-95; AKAP8; AKAP95; AU015639
UniProt ID: (Human) O43823, (Mouse) Q9DBR0
Entrez Gene ID: (Human) 10270, (Mouse) 56399
transcription, DNA-templated
regulation of transcription, DNA-templated
mitotic nuclear division
mitotic chromosome condensation
signal transduction
protein transport
positive regulation of histone deacetylation
regulation of histone phosphorylation
cell cycle G2/M phase transition
innate immune response
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