Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Adenylate kinase 9; adenylate kinase domain containing 1; adenylate kinase domain containing 2; Adenylate kinase domain-containing protein 1; Adenylate kinase domain-containing protein 2; AK 9; RP1-70A9.1
Gene Aliases: AK 9; AK9; AKD1; AKD2; C6orf199; C6orf224; dJ70A9.1
UniProt ID: (Human) Q5TCS8
Entrez Gene ID: (Human) 221264
Molecular Function: nucleotide kinase