Proteintech

AKT2 Polyclonal Antibody

1 Reference
View all (45) AKT2 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

28113-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:600
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunocytochemistry (ICC/IF)

1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

AKT2 Fusion Protein Ag27005

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

550 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

AKT2 is a phosphoinositide-dependent serine/threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone. Akt is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: murine thymoma viral (v-akt) homolog-2; PKB beta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; putative v-akt murine thymoma viral oncoprotein 2; RAC protein kinase beta; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; v-akt murine thymoma viral oncogene homolog 2

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Gene Aliases: 2410016A19Rik; AKT2; AW554154; HIHGHH; PKB; PKBB; PKBBETA; PRKBB; RAC-BETA

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UniProt ID: (Human) P31751, (Mouse) Q60823

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Entrez Gene ID: (Human) 208, (Mouse) 11652

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Function(s)
protein serine/threonine kinase activity protein kinase C binding protein binding ATP binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase protein modifying enzyme
Process(es)
positive regulation of protein phosphorylation glycogen biosynthetic process glucose metabolic process regulation of translation cellular protein modification process apoptotic process response to osmotic stress signal transduction insulin receptor signaling pathway carbohydrate transport positive regulation of signal transduction negative regulation of plasma membrane long-chain fatty acid transport positive regulation of glucose metabolic process response to muscle activity peptidyl-serine phosphorylation regulation of cell migration positive regulation of cell migration positive regulation of vesicle fusion response to nutrient levels positive regulation of fatty acid beta-oxidation peripheral nervous system myelin maintenance cellular response to insulin stimulus negative regulation of RNA splicing positive regulation of peptidyl-serine phosphorylation intracellular signal transduction negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase B signaling positive regulation of nitric oxide biosynthetic process fat cell differentiation positive regulation of glycogen biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import positive regulation of positive chemotaxis mammary gland epithelial cell differentiation intracellular protein transmembrane transport regulation of cell cycle arrest cellular response to organic cyclic compound protein localization to plasma membrane positive regulation of protein targeting to membrane activation of GTPase activity positive regulation of cell motility positive regulation of glucose import in response to insulin stimulus carbohydrate metabolic process glycogen metabolic process protein phosphorylation transport multicellular organism development positive regulation of gene expression positive regulation of sodium ion transport phosphorylation negative regulation of apoptotic process
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