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Huabio
AKT2 Polyclonal Antibody
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FIGURE: 1 / 5
AKT2 Antibody (HA500091) in IHC (P)
Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-AKT2 antibody. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA500091, 1:400) for 30 minutes at room temperature. Th... View More
Product Details
HA500091
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within C-terminal human AKT2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
AKT2 is a phosphoinositide-dependent serine/threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone. Akt is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AKT2 kinase; murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; putative v-akt murine thymoma viral oncoprotein 2; RAC protein kinase beta; RAC protein kinase beta RAC-PK beta; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; unnamed protein product; v-akt murine thymoma viral oncogene homolog 2
Gene Aliases: 2410016A19Rik; AKT2; AW554154; HIHGHH; PKB; PKBB; PKBBETA; PRKBB; RAC-BETA
UniProt ID: (Human) P31751, (Rat) P47197, (Mouse) Q60823
Entrez Gene ID: (Human) 208, (Rat) 25233, (Mouse) 11652
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
metal ion binding
protein serine kinase activity
molecular function activator activity
protein kinase C binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
glycogen metabolic process
glycogen biosynthetic process
glucose metabolic process
regulation of translation
apoptotic process
signal transduction
insulin receptor signaling pathway
negative regulation of plasma membrane long-chain fatty acid transport
positive regulation of glucose metabolic process
regulation of cell migration
positive regulation of cell migration
positive regulation of fatty acid beta-oxidation
peripheral nervous system myelin maintenance
cellular response to insulin stimulus
intracellular signal transduction
protein modification process
negative regulation of apoptotic process
positive regulation of blood vessel endothelial cell migration
fat cell differentiation
positive regulation of glycogen biosynthetic process
positive regulation of glucose import
protein stabilization
regulation of cell cycle
mammary gland epithelial cell differentiation
cellular response to high light intensity
protein localization to plasma membrane
positive regulation of protein targeting to membrane
retinal rod cell apoptotic process
positive regulation of cap-dependent translational initiation
negative regulation of PERK-mediated unfolded protein response
positive regulation of cell motility
positive regulation of protein phosphorylation
protein phosphorylation
response to osmotic stress
multicellular organism development
carbohydrate transport
positive regulation of signal transduction
positive regulation of gene expression
positive regulation of sodium ion transport
response to muscle activity
positive regulation of vesicle fusion
response to nutrient levels
response to insulin
cellular response to hormone stimulus
negative regulation of RNA splicing
positive regulation of peptidyl-serine phosphorylation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of positive chemotaxis
intracellular protein transmembrane transport
cellular response to organic cyclic compound
positive regulation of glucose import in response to insulin stimulus
carbohydrate metabolic process
transport
phosphorylation
activation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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