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Product Details
PA5-88521
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human ALAD (NP_0000223)
Conjugate
Form
liquid
Concentration
1.16 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804972
Product Specific Information
Immunogen sequence: MQPQSVLHSG YFHPLLRAWQ TATTTLNASN LIYPIFVTDV PDDIQPITSL PGVARYGVKR LEEMLRPLVE EGLRCVLIFG VPSRVPKDER GSAADSEESP AIEAIHLLRK TFPNLLVACD VCLCPYTSHG HCGLLSENGA FRAEESRQRL AEVALAYAKA GCQVVAPSDM MDGRVEAIKE ALMAHGLGNR VSVMSYSAKF ASCFYGPFRD AAKSSPAFGD RRCYQLPPGA RGLALRAVDR DVREGADMLM VKPGMPYLDI VREVKDKHPD LPLAVYHVSG EFAMLWHGAQ AGAFDLKAAV LEAMTAFRRA GADIIITYYT PQLLQWLKEE; Positive Samples: HL-60, Mouse liver, Mouse kidney
Target Information
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALADH; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehydratase; Porphobilinogen synthase; testicular tissue protein Li 95
Gene Aliases: ALAD; ALADH; Lv; PBGS
UniProt ID: (Human) P13716, (Mouse) P10518
Entrez Gene ID: (Human) 210, (Mouse) 17025
response to hypoxia
protoporphyrinogen IX biosynthetic process
heme biosynthetic process
response to oxidative stress
response to herbicide
response to iron ion
response to zinc ion
response to aluminum ion
response to ionizing radiation
response to vitamin B1
response to selenium ion
response to activity
response to cobalt ion
response to lipopolysaccharide
response to vitamin E
response to drug
response to amino acid
response to ethanol
response to arsenic-containing substance
response to cadmium ion
response to mercury ion
protein homooligomerization
response to glucocorticoid
response to methylmercury
response to platinum ion
response to fatty acid
cellular response to lead ion
cellular response to interleukin-4
porphyrin-containing compound biosynthetic process
response to nutrient
metabolic process
response to organic substance
response to metal ion
tetrapyrrole biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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