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ALDH1A2 Polyclonal Antibody

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Antibody Testing Data (8)

ALDH1A2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

ALDH1A2 Antibody (13951-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human testis tissue slide using 13951-1-AP ( ALDH1A2 Antibody) at dilution of 1:200 (under 40x lens).

ALDH1A2 Antibody in Immunoprecipitation (IP)

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Product Details

13951-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ALDH1A2 Fusion Protein Ag5062 (181-481 aa encoded by BC030589)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GQIIPWNFP LLMFAWKIAP ALCCGNTVVI KPAEQTPLSA LYMGALIKEV GKLIQEAAGR SNLKRVTLEL GGKSPNIIFA DADLDYAVEQ AHQGVFFNQG QCCTAGSRIF VEESIYEEFV RRSVERAKRR VVGSPFDPTT EQGPQIDKKQ YNKILELIQS GVAEGAKLEC GGKGLGRKGF FIEPTVFSNV TDDMRIAKEE IFGPVQEILR FKTMDEVIER ANNSDFGLVA AVFTNDINKA LTVSSAMQAG TVWINCYNAL NAQSPFGGFK MSGNGREMGE FGLREYSEVK TVTVKIPQKN S (181-481 aa encoded by BC030589)

Target Information

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1.

Clinical and translational medicine

Zhou L,Zhang C,Yang X,Liu L,Hu J,Hou Y,Tao H,Sugimura H,Chen Z,Wang L,Chen K

Tue Jun 01 00:00:00 EDT 2021

Sources of all-trans retinal oxidation independent of the aldehyde dehydrogenase 1A isozymes exist in the postnatal testis†.

Biology of reproduction

Beedle MT,Stevison F,Zhong G,Topping T,Hogarth C,Isoherranen N,Griswold MD

Fri Feb 01 00:00:00 EST 2019

Sources of all-trans retinal oxidation independent of the aldehyde dehydrogenase 1A isozymes exist in the postnatal testis†.

Biology of reproduction

Beedle MT,Stevison F,Zhong G,Topping T,Hogarth C,Isoherranen N,Griswold MD

Fri Feb 01 00:00:00 EST 2019

Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis.

Cell reports

Tang YJ,Huang J,Tsushima H,Ban GI,Zhang H,Oristian KM,Puviindran V,Williams N,Ding X,Ou J,Jung SH,Lee CL,Jiao Y,Chen BJ,Kirsch DG,Alman BA

Tue Sep 10 00:00:00 EDT 2019

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.

eLife

Diaz Osterman CJ,Ozmadenci D,Kleinschmidt EG,Taylor KN,Barrie AM,Jiang S,Bean LM,Sulzmaier FJ,Jean C,Tancioni I,Anderson K,Uryu S,Cordasco EA,Li J,Chen XL,Fu G,Ojalill M,Rappu P,Heino J,Mark AM,Xu G,Fisch KM,Kolev VN,Weaver DT,Pachter JA,Győrffy B,McHale MT,Connolly DC,Molinolo A,Stupack DG,Schlaepfer DD

Tue Sep 03 00:00:00 EDT 2019

ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes.

Biology of reproduction

Kent T,Arnold SL,Fasnacht R,Rowsey R,Mitchell D,Hogarth CA,Isoherranen N,Griswold MD

Fri Jan 01 00:00:00 EST 2016

ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes.

Biology of reproduction

Kent T,Arnold SL,Fasnacht R,Rowsey R,Mitchell D,Hogarth CA,Isoherranen N,Griswold MD

Fri Jan 01 00:00:00 EST 2016

ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes.

Biology of reproduction

Kent T,Arnold SL,Fasnacht R,Rowsey R,Mitchell D,Hogarth CA,Isoherranen N,Griswold MD

Fri Jan 01 00:00:00 EST 2016

ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes.

Biology of reproduction

Kent T,Arnold SL,Fasnacht R,Rowsey R,Mitchell D,Hogarth CA,Isoherranen N,Griswold MD

Fri Jan 01 00:00:00 EST 2016

Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations.

Journal of lipid research

Arnold SL,Kent T,Hogarth CA,Schlatt S,Prasad B,Haenisch M,Walsh T,Muller CH,Griswold MD,Amory JK,Isoherranen N

Sun Feb 01 00:00:00 EST 2015

Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations.

Journal of lipid research

Arnold SL,Kent T,Hogarth CA,Schlatt S,Prasad B,Haenisch M,Walsh T,Muller CH,Griswold MD,Amory JK,Isoherranen N

Sun Feb 01 00:00:00 EST 2015

Retinoic acid signalling is activated in the postischemic heart and may influence remodelling.

PloS one

Bilbija D,Haugen F,Sagave J,Baysa A,Bastani N,Levy FO,Sirsjö A,Blomhoff R,Valen G

Wed Mar 06 00:00:00 EST 2013

Retinoic acid signalling is activated in the postischemic heart and may influence remodelling.

PloS one

Bilbija D,Haugen F,Sagave J,Baysa A,Bastani N,Levy FO,Sirsjö A,Blomhoff R,Valen G

Wed Mar 06 00:00:00 EST 2013

Bioinformatics

Protein Aliases: AL1A2; alcohol dehydrogenase family 1, subfamily A2; alcohol dehydrogenase family 1, subfamily A7; aldehyde dehydrogenase 1 family, member A2; aldehyde dehydrogenase 1A2; Aldehyde dehydrogenase family 1 member A2; aldehyde dehydrogenase family 1, subfamily A2; ALDH1A2; RALDH 2; RALDH(II); ralDH2; Retinal dehydrogenase 2; retinal dehydrogenase, type II; retinaldehyde dehydrogenase 2; Retinaldehyde-specific dehydrogenase type 2

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Gene Aliases: ALDH1A2; Aldh1a7; AV116159; RALDH(II); Raldh-2; Raldh1; RALDH2; RALDH2-T

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UniProt ID: (Human) O94788, (Mouse) Q62148, (Rat) Q63639

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Entrez Gene ID: (Human) 8854, (Mouse) 19378, (Rat) 116676

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Function(s)

retinal dehydrogenase activity 3-chloroallyl aldehyde dehydrogenase activity aldehyde dehydrogenase (NAD) activity retinal binding oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor dehydrogenase oxidoreductase metabolite interconversion enzyme

Process(es)

blood vessel development kidney development liver development regulation of endothelial cell proliferation retinoic acid biosynthetic process heart morphogenesis vitamin A metabolic process midgut development positive regulation of cell proliferation negative regulation of cell proliferation determination of bilateral symmetry anterior/posterior pattern specification proximal/distal pattern formation positive regulation of gene expression neural crest cell development morphogenesis of embryonic epithelium neural tube development pituitary gland development neuron differentiation lung development hindbrain development pancreas development embryonic camera-type eye development response to estradiol response to vitamin A response to cytokine embryonic forelimb morphogenesis ureter maturation retinol metabolic process retinoic acid metabolic process retinal metabolic process 9-cis-retinoic acid biosynthetic process positive regulation of apoptotic process retinoic acid receptor signaling pathway embryonic digestive tract development cardiac muscle tissue development oxidation-reduction process face development cellular response to retinoic acid retinoid metabolic process heart looping heart development metabolic process embryonic limb morphogenesis forebrain development camera-type eye development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ALDH1A2 Polyclonal Antibody

ALDH1A2 Antibody (13951-1-AP) in IHC (P)

Product Details

13951-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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