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Invitrogen
ALDH1A2 Polyclonal Antibody
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FIGURE: 1 / 8
ALDH1A2 Antibody (PA5-22377) in ICC/IF
Immunofluorescence analysis of ALDH1A2 was performed using 70% confluent log phase Jurkat cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with ALDH1A2 Polyclonal Antibody (Product # PA5-22377) at 5 µg/mL in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034... View More
Product Details
PA5-22377
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human ALDH1A2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: IMR32, mouse liver, mouse testis, rat testis.
Predicted reactivity: Mouse (97%), Rat (98%), Xenopus laevis (91%), Dog (99%), Chicken (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AL1A2; alcohol dehydrogenase family 1, subfamily A2; alcohol dehydrogenase family 1, subfamily A7; aldehyde dehydrogenase 1 family, member A2; aldehyde dehydrogenase 1A2; Aldehyde dehydrogenase family 1 member A2; aldehyde dehydrogenase family 1, subfamily A2; ALDH1A2; RALDH 2; RALDH(II); ralDH2; Retinal dehydrogenase 2; retinal dehydrogenase, type II; retinaldehyde dehydrogenase 2; Retinaldehyde-specific dehydrogenase type 2
Gene Aliases: ALDH1A2; Aldh1a7; AV116159; RALDH(II); Raldh-2; Raldh1; RALDH2; RALDH2-T
UniProt ID: (Human) O94788, (Mouse) Q62148, (Rat) Q63639
Entrez Gene ID: (Human) 8854, (Mouse) 19378, (Rat) 116676
retinal dehydrogenase activity
3-chloroallyl aldehyde dehydrogenase activity
aldehyde dehydrogenase (NAD) activity
retinal binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
blood vessel development
kidney development
liver development
regulation of endothelial cell proliferation
retinoic acid biosynthetic process
heart morphogenesis
vitamin A metabolic process
midgut development
positive regulation of cell proliferation
negative regulation of cell proliferation
determination of bilateral symmetry
anterior/posterior pattern specification
proximal/distal pattern formation
positive regulation of gene expression
neural crest cell development
morphogenesis of embryonic epithelium
neural tube development
pituitary gland development
neuron differentiation
lung development
hindbrain development
pancreas development
embryonic camera-type eye development
response to estradiol
response to vitamin A
response to cytokine
embryonic forelimb morphogenesis
ureter maturation
retinol metabolic process
retinoic acid metabolic process
retinal metabolic process
9-cis-retinoic acid biosynthetic process
positive regulation of apoptotic process
retinoic acid receptor signaling pathway
embryonic digestive tract development
cardiac muscle tissue development
oxidation-reduction process
face development
cellular response to retinoic acid
retinoid metabolic process
heart looping
heart development
metabolic process
embryonic limb morphogenesis
forebrain development
camera-type eye development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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