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ALDH1A3 Polyclonal Antibody

ALDH1A3 Antibody in Immunocytochemistry (ICC/IF)

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ALDH1A3 Antibody (25167-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 25167-1-AP (ALDH1A3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

ALDH1A3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

25167-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ALDH1A3 Fusion Protein Ag18605 (1-163 aa encoded by BC069274)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MATANGAVE NGQPDRKPPA LPRPIRNLEV KFTKIFINNE WHESKSGKKF ATCNPSTREQ ICEVEEGDKP DVDKAVEAAQ VAFQRGSPWR RLDALSRGRL LHQLADLVER DRATLAALET MDTGKPFLHA FFIDLEGCIR TLRYFAGWAD KIQGKTIPTD DNVV (1-163 aa encoded by BC069274)

Target Information

ALDH1A3 are aldehyde dehydrogenase isozymes which are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by the ALDH1A3 gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

EGFRvIII Promotes the Proneural-Mesenchymal Transition of Glioblastoma Multiforme and Reduces Its Sensitivity to Temozolomide by Regulating the NF-κB/ALDH1A3 Axis.

Genes

Shi ZF,Li GZ,Zhai Y,Pan CQ,Wang D,Yu MC,Liu C,Zhang W,Yu XG

Sat Mar 04 00:00:00 UTC 2023

EGFRvIII Promotes the Proneural-Mesenchymal Transition of Glioblastoma Multiforme and Reduces Its Sensitivity to Temozolomide by Regulating the NF-κB/ALDH1A3 Axis.

Genes

Shi ZF,Li GZ,Zhai Y,Pan CQ,Wang D,Yu MC,Liu C,Zhang W,Yu XG

Sat Mar 04 00:00:00 UTC 2023

EGFRvIII Promotes the Proneural-Mesenchymal Transition of Glioblastoma Multiforme and Reduces Its Sensitivity to Temozolomide by Regulating the NF-κB/ALDH1A3 Axis.

Genes

Shi ZF,Li GZ,Zhai Y,Pan CQ,Wang D,Yu MC,Liu C,Zhang W,Yu XG

Sat Mar 04 00:00:00 UTC 2023

MiR-195 promotes pancreatic β-cell dedifferentiation by targeting Mfn2 and impairing Pi3k/Akt signaling in type 2 diabetes.

Obesity (Silver Spring, Md.)

Xu Y,Tang Z,Dai H,Hou J,Li F,Tang Z,Zhang D

Tue Feb 01 00:00:00 UTC 2022

RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression.

Cell death & disease

Zhou T,Wang S,Song X,Liu W,Dong F,Huo Y,Zou R,Wang C,Zhang S,Liu W,Sun G,Lin L,Zeng K,Dong X,Guo Q,Yi F,Wang Z,Li X,Jiang B,Cao L,Zhao Y

Fri Apr 15 00:00:00 UTC 2022

ATRA-mediated-crosstalk between stellate cells and Kupffer cells inhibits autophagy and promotes NLRP3 activation in acute liver injury.

Cellular signalling

Yu Z,Xie X,Su X,Lv H,Song S,Liu C,You Y,Tian M,Zhu L,Wang L,Qi J,Zhu Q

Sun May 01 00:00:00 UTC 2022

Autotaxin signaling facilitates β cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency.

Molecular metabolism

Cao H,Chung ACK,Ming X,Mao D,Lee HM,Cao X,Rutter GA,Chan JCN,Tian XY,Kong APS

Wed Jun 01 00:00:00 UTC 2022

Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells.

Journal of cellular and molecular medicine

Zhang J,Yang S,Guan H,Zhou J,Gao Y

Mon Feb 01 00:00:00 UTC 2021

Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons.

Cell chemical biology

Flor A,Wolfgeher D,Li J,Hanakahi LA,Kron SJ

Thu Jun 17 00:00:00 UTC 2021

Flavonoid 4,4'-dimethoxychalcone suppresses cell proliferation via dehydrogenase inhibition and oxidative stress aggravation.

Free radical biology & medicine

Yang C,Zhu S,Chen Y,Liu Z,Zhang W,Zhao C,Luo C,Deng H

Mon Nov 01 00:00:00 UTC 2021

Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.

Nature communications

Le Thomas A,Ferri E,Marsters S,Harnoss JM,Lawrence DA,Zuazo-Gaztelu I,Modrusan Z,Chan S,Solon M,Chalouni C,Li W,Koeppen H,Rudolph J,Wang W,Wu TD,Walter P,Ashkenazi A

Wed Dec 15 00:00:00 UTC 2021

Inhibition of breast cancer growth via miR-7 suppressing ALDH1A3 activity concomitant with decreasing breast cancer stem cell subpopulation.

Journal of cellular physiology

Pan M,Li M,You C,Zhao F,Guo M,Xu H,Li L,Wang L,Dou J

Sat Feb 01 00:00:00 UTC 2020

Inhibition of breast cancer growth via miR-7 suppressing ALDH1A3 activity concomitant with decreasing breast cancer stem cell subpopulation.

Journal of cellular physiology

Pan M,Li M,You C,Zhao F,Guo M,Xu H,Li L,Wang L,Dou J

Sat Feb 01 00:00:00 UTC 2020

Cultivation of Hair Matrix Cells from Cashmere Goat Skins and Exemplified Applications.

Animals : an open access journal from MDPI

Ma S,Wang L,Zong B,Wang Y,Wang X,Shi Y,Yang Y,Chen Y

Wed Aug 12 00:00:00 UTC 2020

Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders.

Cell research

Xu X,Li C,Gao X,Xia K,Guo H,Li Y,Hao Z,Zhang L,Gao D,Xu C,Xu H,Xiong ZQ,Qiu Z,Mei L,Xie X,Ruan K,Hu R

Mon Jan 01 00:00:00 UTC 2018

Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders.

Cell research

Xu X,Li C,Gao X,Xia K,Guo H,Li Y,Hao Z,Zhang L,Gao D,Xu C,Xu H,Xiong ZQ,Qiu Z,Mei L,Xie X,Ruan K,Hu R

Mon Jan 01 00:00:00 UTC 2018

Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells.

Oncotarget

Tamori S,Nozaki Y,Motomura H,Nakane H,Katayama R,Onaga C,Kikuchi E,Shimada N,Suzuki Y,Noike M,Hara Y,Sato K,Sato T,Yamamoto K,Hanawa T,Imai M,Abe R,Yoshimori A,Takasawa R,Tanuma SI,Akimoto K

Fri Nov 23 00:00:00 UTC 2018

Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells.

Oncotarget

Tamori S,Nozaki Y,Motomura H,Nakane H,Katayama R,Onaga C,Kikuchi E,Shimada N,Suzuki Y,Noike M,Hara Y,Sato K,Sato T,Yamamoto K,Hanawa T,Imai M,Abe R,Yoshimori A,Takasawa R,Tanuma SI,Akimoto K

Fri Nov 23 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: acetaldehyde dehydrogenase 6; aldehyde dehydrogenase 1 family, member A3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; aldehyde dehydrogenase family 1, subfamily A3; aldehyde dehydrogenase-6; ALDH1A3; ALDHA1A3; RALDH-3; ralDH3; Retinaldehyde dehydrogenase 3

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Gene Aliases: ALDH1A3; ALDH1A6; ALDH6; MCOP8; RALDH3; V1

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UniProt ID: (Human) P47895, (Mouse) Q9JHW9, (Rat) Q8K4D8

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Entrez Gene ID: (Human) 220, (Mouse) 56847, (Rat) 266603

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Function(s)

retinal dehydrogenase activity aldehyde dehydrogenase (NAD) activity aldehyde dehydrogenase [NAD(P)+] activity protein homodimerization activity thyroid hormone binding NAD+ binding 3-chloroallyl aldehyde dehydrogenase activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor dehydrogenase oxidoreductase metabolite interconversion enzyme

Process(es)

optic cup morphogenesis involved in camera-type eye development retinoic acid biosynthetic process locomotory behavior nucleus accumbens development inner ear morphogenesis retinol metabolic process retinoic acid metabolic process retinal metabolic process positive regulation of apoptotic process embryonic eye morphogenesis neuromuscular process controlling balance oxidation-reduction process righting reflex olfactory pit development face development cellular aldehyde metabolic process metabolic process embryonic camera-type eye development positive regulation of retinoic acid receptor signaling pathway kidney development pituitary gland development response to drug

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ALDH1A3 Polyclonal Antibody

ALDH1A3 Antibody (25167-1-AP) in ICC/IF

Product Details

25167-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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