Immunogen sequence: FGNDGKALTV RNLQFEDGKM IPASQYFSTG ETSVVELTAE EVKVAETIKV IWAGILSNVP
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
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Protein Aliases: 10-formyltetrahydrofolate dehydrogenase ALDH1L2; aldehyde dehydrogenase 1 family, member L2; Aldehyde dehydrogenase family 1 member L2; aldehyde dehydrogenase family 1 member L2, mitochondrial; ALDH1L2; Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Mitochondrial 10-FTHFDH; mtFDH; probable 10-formyltetrahydrofolate dehydrogenase ALDH1L2
Gene Aliases: ALDH1L2; mtFDH
UniProt ID: (Human) Q3SY69
Entrez Gene ID: (Human) 160428