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Product Details
PA5-120435
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 250-320 of human ALDH3A2 (NP_001026976.1).
Conjugate
Form
Liquid
Concentration
2.13 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914007
Product Specific Information
Positive test controls include: A-549, Mouse testis, Rat kidney. The target is usually found in the following locations: Cytoplasmic side, Endoplasmic reticulum membrane, Single-pass membrane protein.^M
^M
Immunogen sequence: EASLQNQIVW KIKETVKEFY GENIKESPDY ERIINLRHFK RILSLLEGQK IAFGGETDEA TRYIAPTVLT D
Target Information
Aldh3A2 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh3A2 catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Mutations in the Aldh3A2 gene cause Sjogren-Larrson syndrome, an inherited neurocutaneous disorder. Patients with this disorder display ichthyosis, mental retardation and spastic diplegia. The pathogenesis of the cutaneous and neurological symptoms is thought to result from abnormal lipid accumulation in the membranes of skin and brain, the formation of aldehyde Schiff base adducts with amine-containing lipids or proteins, or defective eicosanoid metabolism.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alcohol dehydrogenase family 3, subfamily A2; Aldehyde dehydrogenase 10; Aldehyde dehydrogenase 3; aldehyde dehydrogenase 3 family, member A2; aldehyde dehydrogenase 3A2; Aldehyde dehydrogenase 4; Aldehyde dehydrogenase family 3 member A2; aldehyde dehydrogenase family 3, subfamily A2; DKFZp686E23276; Fatty aldehyde dehydrogenase; FLJ20851; Microsomal aldehyde dehydrogenase; msALDH
Gene Aliases: Ahd-3; Ahd-3r; Ahd3; Ahd3-r; AI194803; ALDH10; Aldh3; ALDH3A2; Aldh4; Aldh4-r; FALDH; SLS
UniProt ID: (Human) P51648, (Rat) P30839, (Mouse) P47740
Entrez Gene ID: (Human) 224, (Rat) 65183, (Mouse) 11671
response to reactive oxygen species
fatty acid alpha-oxidation
cellular aldehyde metabolic process
central nervous system development
peripheral nervous system development
epidermis development
sphingolipid biosynthetic process
phytol metabolic process
formaldehyde metabolic process
oxidation-reduction process
sesquiterpenoid metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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