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Proteintech
ALDH5A1 Polyclonal Antibody
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Product Details
17319-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ALDH5A1 Fusion Protein Ag11293 (175-535 aa encoded by BC034321)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YGDIIHTPA KDRRALVLKQ PIGVAAVITP WNFPSAMITR KVGAALAAGC TVVVKPAEDT PFSALALAEL ASQAGIPSGV YNVIPCSRKN AKEVGEAICT DPLVSKISFT GSTTTGKILL HHAANSVKRV SMELGGLAPF IVFDSANVDQ AVAGAMASKF RNTGQTCVCS NQFLVQRGIH DAFVKAFAEA MKKNLRVGNG FEEGTTQGPL INEKAVEKVE KQVNDAVSKG ATVVTGGKRH QLGKNFFEPT LLCNVTQDML CTHEETFGPL APVIKFDTEE EAIAIANAAD VGLAGYFYSQ DPAQIWRVAE QLEVGMVGVN EGLISSVECP FGGVKQSGLG REGSKYGIDE YLELKYVCYG GL (175-535 aa encoded by BC034321)
Target Information
Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA). Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: aldehyde dehydrogenase 1, mitochondrial; aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase); Aldehyde dehydrogenase family 5 member A1; aldehyde dehydrogenase family 5, subfamily A1; mitochondrial succinate semialdehyde dehydrogenase; NAD(+)-dependent succinic semialdehyde dehydrogenase; Succinate-semialdehyde dehydrogenase, mitochondrial; succinic semialdehyde dehydrogenase; unnamed protein product
Gene Aliases: 6330403E24Rik; Ahd-1; Ahd1; ALDH5A1; D630032B01Rik; OTTMUSG00000000613; SSADH; SSDH; Ssdh1
UniProt ID: (Human) P51649, (Mouse) Q8BWF0
Entrez Gene ID: (Human) 7915, (Mouse) 214579, (Rat) 291133
succinate-semialdehyde dehydrogenase (NAD+) activity
succinate-semialdehyde dehydrogenase [NAD(P)+] activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
identical protein binding
aldehyde dehydrogenase (NAD) activity
carboxylic acid binding
NAD binding
dehydrogenase
succinate metabolic process
glutamate metabolic process
central nervous system development
gamma-aminobutyric acid metabolic process
gamma-aminobutyric acid catabolic process
post-embryonic development
carboxylic acid metabolic process
synaptic transmission, GABAergic
glucose metabolic process
acetate metabolic process
glutamine metabolic process
glycerophospholipid metabolic process
glucosylceramide metabolic process
galactosylceramide metabolic process
glutathione metabolic process
metabolic process
respiratory electron transport chain
neurotransmitter catabolic process
short-chain fatty acid metabolic process
protein homotetramerization
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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